Conclusion
Clinical manifestation of severe eczema, recurrent sinopulmonary infections, and initial immunologic workup revealing of HIES-like disorders should prompt further investigation of possible contributory genes. This case highlights the potential involvement of variant of unknown significant in PGM3 gene. To treat the persistent eczema refractory to topical and systemic corticosteroids, we urge clinicians to recognize dupilumab as an efficacious alternative with high safety profile.