Conclusion
Clinical manifestation of severe eczema, recurrent sinopulmonary
infections, and initial immunologic workup revealing of HIES-like
disorders should prompt further investigation of possible contributory
genes. This case highlights the potential involvement of variant of
unknown significant in PGM3 gene. To treat the persistent eczema
refractory to topical and systemic corticosteroids, we urge clinicians
to recognize dupilumab as an efficacious alternative with high safety
profile.