References:
1. Schoettler, N., et al. New Insights Relating Gasdermin B to the Onset of Childhood Asthma. Am J Respir Cell Mol Biol 67 , 430-437 (2022).
2. Broz, P., Pelegrin, P. & Shao, F. The gasdermins, a protein family executing cell death and inflammation.Nat Rev Immunol 20 , 143-157 (2020).
3. Panganiban, R.A., et al. A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis. J Allergy Clin Immunol 142 , 1469-1478 e1462 (2018).
4. Zhou, Z., et al. Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells. Science 368 (2020).
5. Holgate, S.T., et al.Asthma. Nat Rev Dis Primers 1 , 15025 (2015).
6. Lambrecht, B.N. & Hammad, H. Allergens and the airway epithelium response: gateway to allergic sensitization. J Allergy Clin Immunol 134 , 499-507 (2014).
Ronald Allan M. Panganiban, Jin-Ah Park, and Quan Lu*
Program in Molecular and Integrative Physiological Sciences
Department of Environmental Health
Harvard T.H. Chan School of Public Health
Boston, Massachusetts 02115 USA
*Corresponding author: Harvard T.H. Chan School of Public Health, Building 1, Room 309, 665 Huntington Ave, Boston, MA 02115. E-mail: qlu@hsph.harvard.edu
Ronald Allan M. Panganiban (ORCID: 0000-0003-0894-1318)
Jin-Ah Park (ORCID: 0000-0002-8930-9287)
Quan Lu (ORCID: 0000-0003-3915-0762)