References:
1. Schoettler, N., et al. New
Insights Relating Gasdermin B to the Onset of Childhood Asthma. Am
J Respir Cell Mol Biol 67 , 430-437 (2022).
2. Broz, P., Pelegrin, P. & Shao, F.
The gasdermins, a protein family executing cell death and inflammation.Nat Rev Immunol 20 , 143-157 (2020).
3. Panganiban, R.A., et al. A
functional splice variant associated with decreased asthma risk
abolishes the ability of gasdermin B to induce epithelial cell
pyroptosis. J Allergy Clin Immunol 142 , 1469-1478 e1462
(2018).
4. Zhou, Z., et al. Granzyme A
from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target
cells. Science 368 (2020).
5. Holgate, S.T., et al.Asthma. Nat Rev Dis Primers 1 , 15025 (2015).
6. Lambrecht, B.N. & Hammad, H.
Allergens and the airway epithelium response: gateway to allergic
sensitization. J Allergy Clin Immunol 134 , 499-507
(2014).
Ronald Allan M. Panganiban, Jin-Ah Park, and Quan Lu*
Program in Molecular and Integrative Physiological Sciences
Department of Environmental Health
Harvard T.H. Chan School of Public Health
Boston, Massachusetts 02115 USA
*Corresponding author: Harvard T.H. Chan School of
Public Health, Building 1, Room 309, 665 Huntington Ave, Boston, MA
02115. E-mail: qlu@hsph.harvard.edu
Ronald Allan M. Panganiban (ORCID: 0000-0003-0894-1318)
Jin-Ah Park (ORCID: 0000-0002-8930-9287)
Quan Lu (ORCID: 0000-0003-3915-0762)