Acknowledgements
We thank Liu lab members for discussion. We thank Prof. Haiteng Deng and Dr. Xianbin Meng in Protein Chemistry and Proteomics Facility at Technology Center for Protein Sciences, Tsinghua University, for assistance in protein MS analysis. The work was financially supported by grants from National Key Research and Development Program of China (2022YFA1304500), the Natural Science Foundation of China (22174003 and 21974002), Peking University Medicine Seed Fund for Interdisciplinary Research and the Fundamental Research Funds for the Central Universities.