Methods
Cedars-Sinai Medical Center (CSMC) Institutional Review Board approved
this retrospective study. The data from 28 patients, less than 21 years
old, who underwent a minimum of 3 months of chemotherapy was collected
from a list of CCS followed at CSMC (Los Angeles, CA) between January 1,
2010 and July 31, 2022, see table 1. Confirmation of primary vaccine
series completion, either through available vaccination records or
documentation in a physician note, was required to be included in the
study. Exclusion criteria included relapsed disease, HSCT, or having
received intravenous immunoglobulin (IVIG) within 6 months of the titer
collection. All redrawn samples that occurred within 3 months of the
original titer collection were grouped together. Serum antibody levels
for measles, mumps, rubella, varicella, tetanus, and hepatitis B were
measured between 1 month and 30 months after the conclusion of
chemotherapy.
Table 1: Patient demographic, diagnosis, and duration of treatment