This essay presents recent advances in Pd-catalyzed asymmetric allylic
C-H functionalization in our lab, including the development of
asymmetric catalytic systems, the mechanism of allylic C−H activation
and the control of stereo- and regioselectivity. A diverse range of
α-alkenes have been active allylic reagents to engage in the reactions
to access synthetically useful building blocks, enabling the asymmetric
synthesis of a range of natural products and biologically
molecules. |