3.2 Signal values associated with hepatic dysfunction at SOC level
For the specific comparisons, there was a strong signal for increased hepatic dysfunction risk, when comparing voriconazole with the full database (Fig.2) , the ROR was 6.82 (95% CI 6.26-7.42). Comparing to the other antifungal drugs, voriconazole significantly increased the risk of hepatic dysfunction compared with fluconazole, isavuconazole and amphotericin B, with the RORs 2.19 (95% CI 1.94-2.47), 2.31 (95% CI 1.66-3.33) and 1.26 (95% CI 1.08-1.48), respectively. Analysis showed that voriconazole was not associated with a higher risk of hepatic dysfunction compared with itraconazole, posaconazole, caspofungin, micafungin, anidulafungin and 5-fluorocytosine (RORs 1.06 (95% CI 0.88-1.28), 1.08 (95% CI 0.89-1.30), 0.81 (95% CI 0.68-0.96), 0.75 (95% CI 0.62-0.90), 1.50 (95% CI 0.94-2.39), 1.00 (95% CI 0.44-2.27), respectively).