3.2. Gene expression of OCTN transporters in HTR-8/SVneo cells
upon inflammatory stimulation
In parallel to BeWo cells, another placental cellular model, the
HTR-8/SVneo cells have been investigated for the changes in OCTN1and OCTN2 transporter expression (Fig. 2 A, B) during
inflammatory stimulation. As shown in Fig. 2 A, IFN-γ and TNF-α were
able to increase the expression of SLC22A4 after 72 h exposition.
In the gene expression of SLC22A5 (Fig. 2 B) the statistical
significance was observed with IFN-γ stimulation after 48 and 72 h.
Neither IL-6 or any of the inflammation stimulators LPS or HMGB1 did
affect the expression of OCTN1 and OCTN2 encoding genes.