Fig. 3. Treadmill exercise prevented stress-induced anxiety- like behavior in open field test. ##p<0.01 and###P<0.001 vs. C group;**p<0.01 and ***P<0.05 vs. VD group.
VD-induced recognition memory impairment was ameliorated by treadmill exercise
As shown in Fig. 4, the discrimination index of each group were obtained by recognition memory test. When compared with control rats, the discrimination index of VD rats was significantly lesser (P<0.05, P<0.01; Fig. 4B). Conversely, the discrimination index of Exe-VD rats was significantly greater than VD rats (P<0.05, P<0.01; Fig. 4B). Thus, these findings thus indicate that treadmill exercise rescued recognition memory impairment in VD model.