Bulleted point summary:
- The transcriptome profile revealed that Bazhen decoction might
systematically regulate multiple anti-aging pathways, including stem
cell regulation, protein homeostasis, cardiovascular function,
neuronal function, anti-inflammation, anti-DNA damage induced stress,
DNA helicase activity and telomere lengthening.
- Bazhen decoction could up-regulate multiple DNA helicases and telomere
regulating proteins, promote the resolving of G-quadruplex (G4)
structure, and facilitate DNA replication and telomere elongation.
- Bazhen decoction could endow the cellular resistance to DNA damages
induced by replication stress.
- Our data revealed a new strategy for recovering the pharmacological
signature pathways for TCM, which could help the clinical precision
medicine of TCM.