5. Conclusion
Synthetic cannabinoid JWH-018 beside known psychoactive properties has some detrimental cardiac and vascular effects such as tachycardia, bradycardia, hypotension, arrhythmia and QT prolongation depend on the dose and duration of application. It seems that JWH-018 has dose and duration-dependent increase or decrease in heart rate, high-dose-related decrease in blood pressure, cardiac arrhythmia, conduction blocks, and ischemic ECG changes. The information presented in this study suggests that SCs should not be thought of as secure and authorized substitutes for cannabis. Instead, the increased toxicity of SCs may be as a result of the interactions between the many SCs present and their active metabolites that still have a high affinity for CB1 and CB2 receptors, emphasizing the potential risk associated with using these drugs.