Conclusion
Here, we present a case of disseminated aspergillus infection in the setting of zanubrutinib use in a patient with marginal zone lymphoma. His clinical course was likely impacted by a prolonged steroid course which resulted in dysfunction of his innate immune system and neutropenia in the setting of BTKi administration. Due to the limited time that this medication has been on the market and the limited number of published cases pertaining to adverse events, it is difficult to assess whether or not the greater propensity of neutropenia in zanubrutinib increases the likelihood of fungal infection. Zanubrutinib may also play a role in decreased neutrophil function in the remaining cells present. We expect that there will be greater understanding as additional cases are presented.