Per TMP set-point a maximum of two representative experiments are presented here.
A “>” preceding the logarithmic reduction factor (R) combined with a “no” result for the parameter “virus breakthrough” indicates removal below the limit of detection for all of the filtrate fractions.
If minimal virus infectivity was found in a minority of the filtrate fractions (i.e., the titers were at the limit of detection) then the result for virus-breakthrough is “minimal”.
A “minor” virus breakthrough indicates that minimal infectivity was found in the majority of the filtrate fractions.
Table 3. Filtration conditions and results for MMV retention – 2nd generation filter II (SG II) – ASAHI Planova BioEX.