6.1.3 Autophagy
Hydrogen sulfide protects cardiomyocytes through a bidirectional action
in autophagy[117]. Tissue or cellular ischemia
leads to the development of cellular autophagy, and moderate cellular
autophagy facilitates the repair of damaged cells. It has been
demonstrated that hydrogen sulfide can exert cytoprotective effects by
promoting autophagy, which seems to be associated with NLRP3
inflammatory vesicles. Excessive autophagy exacerbates cellular I/R
injury, and H2S can activate PI3K/SGK1/GSK3β signaling
pathway and PI3K/Art/mTOR signaling pathway to inhibit autophagy and
provide protection for I/R-injured
cardiomyocytes[118, 119].