4.4 Natural hydrogen sulfide donors and derivatives
Some natural foods can also serve as donors of hydrogen sulfide. Garlic
is considered a good preventive food and has been found to have great
medicinal research value[70, 71]. Allicin is a
metabolic active substance in garlic, which can be decomposed to produce
diallyl polysulfides, such as diallyl sulfides (DAS), diallyl disulfides
(DADS) and diallyl trisulfides (DATS)[72].And
these sulfides can react with thiol groups (glutathione) to produce
hydrogen sulfide[73]. However, due to the rapid
release of hydrogen sulfide in water by DATS, some laboratories have
utilized exploiting mesoporous silica nanoparticles(MSN)as a carrier
to construct a new H2S release system
(DATS-MSN)[74]. DATS-MSN can release
H2S more slowly and controllably. In this study,
compared to traditional H2S donors (NaHS, DATS, and
GYY4137), DATS-MSN showed better cardioprotective
effects[74].