6.1.5 Protection of mitochondria
The role of mitochondria is particularly important in mammalian growth
and development, providing energy for the basic metabolism of the body.
When myocardial I/R occurs, the function of mitochondria is severely
impaired, leading to further myocardial damage. It has been found that
NaHS can reduce mitochondrial malondialdehyde levels in ischemic
cardiomyocytes, while elevating the activities of superoxide dismutase
and glutathione peroxidase, allowing the preservation of mitochondrial
function[127]. In addition, H2S
also increased the efficiency of complexes I and II of the oxidative
respiratory chain in mitochondria and inhibited cytochrome oxidase,
reducing the metabolism of cardiomyocytes to a preconditioned state,
thereby reducing cardiomyocyte damage[128, 129].