4.4 Natural hydrogen sulfide donors and derivatives
Some natural foods can also serve as donors of hydrogen sulfide. Garlic is considered a good preventive food and has been found to have great medicinal research value[70, 71]. Allicin is a metabolic active substance in garlic, which can be decomposed to produce diallyl polysulfides, such as diallyl sulfides (DAS), diallyl disulfides (DADS) and diallyl trisulfides (DATS)[72].And these sulfides can react with thiol groups (glutathione) to produce hydrogen sulfide[73]. However, due to the rapid release of hydrogen sulfide in water by DATS, some laboratories have utilized exploiting mesoporous silica nanoparticles(MSN)as a carrier to construct a new H2S release system (DATS-MSN)[74]. DATS-MSN can release H2S more slowly and controllably. In this study, compared to traditional H2S donors (NaHS, DATS, and GYY4137), DATS-MSN showed better cardioprotective effects[74].