CONCLUSIONS
To date, this is the largest South Korean study on HIV-1 subtype analysis and drug resistance surveillance, presenting the overall prevalence of TDRM from 2017 to 2022. The proportion of non-B subtypes of HIV-1 infections has recently increased rapidly, with CRF01_AE becoming the predominant non-B subtype in South Korea. Moreover, an overall decrease in TDRM was observed in recent years. In particular, TDRM prevalence decreased in NRTIs and INSTIs. However, considering that DRMs are detected in more than 20% of ART-naïve patients, routine GART is strongly recommended before ART treatment. Routine GART surveillance will also improve HIV prevention and control the development of drug resistance.