Subtype trends of HIV‑1
Temporal trends showed that the proportion of non-B subtype infection
increased during the observation period from 15.3% before 2018 to
33.3% in 2022, stratified by the initial diagnosis of HIV infection
(Figure 2). Among the 512 patients with non-B subtype infections,
CRF01_AE (64.8%, 332/512) was the most prevalent, followed by
CRF02_AG (10.9%, 56/512), subtype A (10.4%, 53/512), CRF56_cpx
(4.7%, 24/512), subtype C (3.7%, 19/512), CRF07_BC (2.3%, 12/512),
subtype G (1.0%, 5/512), and other subtypes (2.1%, 11/512) such as
CRF06_cpx, CRF55_01B, and subtype D. The distribution within non-B
subtypes also changed over time. The proportion of CRF01_AE increased
from 58.4% to 73.7% from 2018 to 2022, whereas that of CRF02_AG
decreased from 11.7% to 3.0%.