CONCLUSIONS
To date, this is the largest South Korean study on HIV-1 subtype
analysis and drug resistance surveillance, presenting the overall
prevalence of TDRM from 2017 to 2022. The proportion of non-B subtypes
of HIV-1 infections has recently increased rapidly, with CRF01_AE
becoming the predominant non-B subtype in South Korea. Moreover, an
overall decrease in TDRM was observed in recent years. In particular,
TDRM prevalence decreased in NRTIs and INSTIs. However, considering that
DRMs are detected in more than 20% of ART-naïve patients, routine GART
is strongly recommended before ART treatment. Routine GART surveillance
will also improve HIV prevention and control the development of drug
resistance.