IP-10 responses in Mtb.-infected and uninfected children
IP-10 responses in Mtb . antigen-stimulated, unstimulated, and
mitogen stimulated supernatants are presented in Table 2. UponMtb. antigen stimulation the expression of IP-10 augmented
significantly only in Mtb.- infected children (p <
0.0001).
Mtb. antigen-stimulated IP-10 responses were much higher inMtb.- infected than in Mtb. -uninfected children (p
< 0.0001). We then compared IP-10 levels between the subgroups
of infected and uninfected children (ATB and LTBI vs TB contacts,
non-TB, and controls separately) and the differences in IP-10 levels
were still significant (p < 0.0001 for all pairwise
comparisons) (Figure 1). While IP-10 level was higher in ATB than in
LTBI group (p = 0.047), no differences were demonstrated amongMtb. -uninfected groups (p > 0.05).