2.3 Implantation of blood pressure telemetry implant
The rats were injected intraperitoneally with a pentobarbital-normal saline solution (50mg/kg) for anesthesia before undergoing the implantation procedure, which involved the following steps: performing an abdominal incision surgery on the rats and separating their abdominal aorta; injecting a blood pressure detection probe into the abdominal aorta and securing it to the abdominal wall; suturing the muscles and skin and administering subcutaneous injections of meloxicam (1mg/kg) for pain relief and gentamicin (5mg/kg) for infection prevention; placing the rats on a constant temperature blanket and feeding them separately after they regained consciousness. Additionally, subcutaneous injections of meloxicam (1mg/kg) for pain relief and gentamicin (5mg/kg) for infection prevention were also administered daily for three days after surgery.