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Combined peripheral and central ultrasound for diagnosis of PAH-SSc patients.
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  • Michele Correale,
  • Cinzia Rotondo,
  • Ester Maria Lucia Bevere,
  • Lucia Tricarico,
  • Valeria Rella,
  • Deborah Villani,
  • Mattia Granato,
  • Celeste Migliozzi,
  • Francesco Paolo Cantatore,
  • Natale Daniele Brunetti,
  • Addolorata Corrado
Michele Correale
Azienda Ospedaliera Universitaria Foggia

Corresponding Author:[email protected]

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Cinzia Rotondo
University of Foggia
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Ester Maria Lucia Bevere
Universita degli Studi di Foggia Dipartimento di Scienze Mediche e Chirurgiche
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Lucia Tricarico
Universita degli Studi di Foggia Dipartimento di Scienze Mediche e Chirurgiche
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Valeria Rella
University of Foggia
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Deborah Villani
Universita degli Studi di Foggia Dipartimento di Scienze Mediche e Chirurgiche
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Mattia Granato
Universita degli Studi di Foggia Dipartimento di Scienze Mediche e Chirurgiche
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Celeste Migliozzi
Universita degli Studi di Foggia Dipartimento di Scienze Mediche e Chirurgiche
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Francesco Paolo Cantatore
University of Foggia
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Natale Daniele Brunetti
Universita degli Studi di Foggia Dipartimento di Scienze Mediche e Chirurgiche
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Addolorata Corrado
University of Foggia
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Abstract

Background: Systemic Sclerosis (SSc), an intricate autoimmune disease causing tissue fibrosis, introduces cardiovascular complexities, notably pulmonary hypertension (PH), affecting both survival and quality of life. This study centers on evaluating echocardiographic parameters and endothelial function using Flow Mediated Dilatation (FMD) in SSc patients, aiming to differentiate those with and without pulmonary arterial hypertension (PAH). The emphasis lies in early detection, given the heightened vulnerability of the right ventricle in the presence of PH. Methods: 59 SSc patients and 48 healthy subjects participated, undergoing clinical examinations, echocardiography, FMD assessments, blood analyses, and, when necessary, right heart catheterization (RHC). Results: SSc-PAH patients displayed lower FMD, increased TAPSE <18 mm, RA area >18 cm2, and TRV >280 cm/sec compared to those without PAH and healthy controls. Resting Resistivity Index (RI) was higher in SSc patients, with no significant difference between those with and without PAH. Lower FMD% serves as a predictive marker for adverse cardiovascular outcomes in both SSc and SSc-PAH patients. Stratification by TRV levels and PAH presence reveals notable FMD% variations, emphasizing its potential utility. Conclusions: Early identification of endothelial dysfunction and echocardiographic parameters, such as TAPSE and TRV, could aid in predicting right ventricular dysfunction and PAH in SSc patients.
18 Mar 2024Submitted to Echocardiography
18 Mar 2024Review(s) Completed, Editorial Evaluation Pending
11 Apr 2024Editorial Decision: Revise Major
14 May 2024Submission Checks Completed
14 May 2024Assigned to Editor
14 May 2024Review(s) Completed, Editorial Evaluation Pending
18 May 2024Editorial Decision: Accept