3 Materials and methods
3.1 Data source and collection
We used data from the FAERS database published between January 2004 and December 2021. Reports on adverse event and medication error in the FAERS database was spontaneous reported by medical workers, consumers, and manufacturers globally[22]. Each FAERS report contain patients demographic information(age, gender and weight), drug information(indication, dosage, and interval of administration), adverse events information(occurrence time, outcome) and other information(report year, report country and reporter occupations). In the circumstances that there were multiple reports of the same event, deduplicated procedure were perform in accordance with FDA recommendation.