Summary of major algorithms used for signal detection. |
Summary of
major algorithms used for signal detection. |
Summary of major
algorithms used for signal detection. |
Method |
Calculation formulas |
Judgement criteria |
ROR |
ROR=ad/bc |
95%CI>1,N≥3 |
|
95%CI=eln(ROR)±1.96(1/a+1/b+1/c+1/d)^0.5 |
|
PRR |
PRR=a(c+d)/c(a+b) |
PRR≥2,χ2≥4,N≥3 |
|
χ2=[(ad-bc)^2](a+b+c+d)/[(a+b)(c+d)(a+c)(b+d)] |
|
BCPNN |
IC = log2a(a + b + c + d)(a + c)(a + b) |
IC025> 0 |
|
95% CI = eln(IC) ± 1.96(1/a+1/b+1/c+1/d)^0.5
|
|
MGPS |
EBGM = a(a + b + c + d)/(a + c)/(a + b) |
EBGM05>
2, |
|
95% CI = eln(EBGM) ± 1.96(1/a+1/b+1/c+1/d)^0.5
|
N>0 |
a:the number of reports with suspect drug adverse event of the suspect
drug; b:the number of reports with the suspect AE of all other drugs,;
c:the number of reports with all other AEs of the suspect drug; d: the
number of reports with all other AEs of all other drugs; N:the number of
co-occurrences; BCPNN:Bayesian confidence propagation neural network;
CI:confidence interval; EBGM:empirical Bayesian geometric mean;
EBGM05:the lower 95% one-sided CI of EBGMIC; IC: information component;
IC025: the lower limit of the 95% two-sided CI of the IC;
MGPS:multi-item gamma Poisson shrinker; PRR Proportional Reporting
Ratio; ROR:Reporting Odds Ratio; χ2:chi-squared. |
a:the number of
reports with suspect drug adverse event of the suspect drug; b:the
number of reports with the suspect AE of all other drugs,; c:the number
of reports with all other AEs of the suspect drug; d: the number of
reports with all other AEs of all other drugs; N:the number of
co-occurrences; BCPNN:Bayesian confidence propagation neural network;
CI:confidence interval; EBGM:empirical Bayesian geometric mean;
EBGM05:the lower 95% one-sided CI of EBGMIC; IC: information component;
IC025: the lower limit of the 95% two-sided CI of the IC;
MGPS:multi-item gamma Poisson shrinker; PRR Proportional Reporting
Ratio; ROR:Reporting Odds Ratio; χ2:chi-squared. |
a:the number of
reports with suspect drug adverse event of the suspect drug; b:the
number of reports with the suspect AE of all other drugs,; c:the number
of reports with all other AEs of the suspect drug; d: the number of
reports with all other AEs of all other drugs; N:the number of
co-occurrences; BCPNN:Bayesian confidence propagation neural network;
CI:confidence interval; EBGM:empirical Bayesian geometric mean;
EBGM05:the lower 95% one-sided CI of EBGMIC; IC: information component;
IC025: the lower limit of the 95% two-sided CI of the IC;
MGPS:multi-item gamma Poisson shrinker; PRR Proportional Reporting
Ratio; ROR:Reporting Odds Ratio; χ2:chi-squared. |