ACKNOWLEDGEMENTS

I would like to thank all the members of PEZY Computing K. K. for supporting my research. I would also like to thank the National Institute of Genetics and RIKEN for supporting the metagenomic projects and PZLAST. I sincerely thank Dr. Wei Zheng for the insightful discussions. I am deeply grateful to Prof. Arne Elofsson and Dr. Claudio Mirabello for publicly sharing baseline MSAs and predictions. I would also like to thank the ColabFold team for providing the results with easy-to-use web interfaces. I am grateful to DeepMind Technologies Limited for providing the code and parameters of AlphaFold2 and AlphaFold-Multimer under generous licenses. I am grateful to the developers and maintainers of the software and databases used in the pipeline and used in this analysis. I would like to thank Editage (www.editage.com) for English language editing. Additionally, I would like to thank ChatGPT, DeepL, Grammarly, and Paperpal for their insightful suggestions to improve my English text.