Part I
Chemical and reagents
The following compounds were obtained from Aladdin: Fostamatinib (Lot No.: J1508085), Ponatinib (Lot No.: F1511088), Axitinib (Lot No.: I1410008), Crizotinib (Lot No.: I1828093), Venetoclax (Lot No.: C1608065), Ibrutinib (Lot No.: C1808046), Nintedanib (Lot No.: G1524093), Rivaroxaban (Lot No.: E1522122), Apixaban (Lot No.: D2007114), Ospemifene (Lot No.: F1702014), Roflumilast (Lot No.: I1828049), Suvorexant (Lot No.: H1504094), Vilazodone (Lot No.: E1712149), Apremilast (Lot No.: B2102013), Elagolix (Lot No.: K2109038), Istradefylline (Lot No.: E1624040), Panobinostat (Lot No.: D1510023), Rolapitant (Lot No.: F2214052), Tasimelteon (Lot No.: H2118249), Vorapaxar (Lot No.: G2216638), Fedratinib (Lot No.: E1719007), Lenvatinib (Lot No.: J1520104), Pomalidomide (Lot No.: F1524104), Ruxolitinib (Lot No.: C1926101), Telaprevir (Lot No.: F1515073), Baricitinib (Lot No.: B1512012), Macitentan (Lot No.: H1507106), Safinamide (Lot No.: E1529132), Tofacitinib (Lot No.: I1925019), Bosutinib (Lot No.: B1512016), Sonidegib (Lot No.: S215103), and Testosterone (Lot No.: F2126139). Additionally, Flibanserin (Lot No.: 17354), and Edoxaban (Lot No.: 41922) were obtained from MedChemExpress, and Tolbutamide (Lot No.: BCCF4700) was purchased from Sigma-Aldrich. Ketoconazole (Lot No.: LF90U63) was purchased from J&K Scientific. Ultrapure water was produced using an Ultrapure-Water Generating System, and PBS (PH7.4) was purchased from BasalMedia. Finally, HLM (Lot No.:2010065) were purchased from XenoTech.