Construction of excipient allergy registry – using PEG as an example
An excipient registry was constructed based on the top 50 reported drug allergy culprits as retrieved from CEDAR. In view of the recent relevance for mRNA vaccines, PEG was selected as the pilot registry. An excipient registry was created by compiling the excipient lists pertaining to all available formulations of each of the drugs of the top 50 most implicated drug allergies. All excipient lists from drug product inserts, and if unavailable, through contacting individual pharmaceutical companies - as there is no pharmaceutical legislation to mandate listing of excipients of registered drugs in Hong Kong. Depending on the status of PEG, formulations were then categorised as either ‘contains PEG’, ‘does not contain PEG’, or ‘unknown’.