Autoimmune Connective Tissue Disease Main autoantigens Prevalence of autoreactive IgG Autoreactive IgG titers associated with disease activity? Ref Prevalence of autoreactive IgE Autoreactive IgE titers associated with disease activity? Ref
Systemic Lupus Erythematosus (SLE) ANA 69-90% Yes 28,43 48-65% Yes 24,28
dsDNA 34-49% Yes 28,44 35-55% Yes (especially with lupus nephritis 28,29) 23,27-29,33
Sm 41-50% Yes 28,44 7-48% Yes 28,44
Ro/SS-A 34% Yes 28,44 8-48% Yes 28,44
La/SS-B 7% Yes 28,44 4-7% Yes 28,44
Mixed Connective Tissue Disease (MCTD) U1-snRNP 100% 38 79% NA 38
Gougerot-Sjögren syndrome (GS) Ro/SS-A 73% Yes 45 33% NA 46
La/SS-B 45% Yes 45 41% NA 46
dsDNA 0% NA 47 15% NA 46
Sm 1-7% NA 46,47 25% NA 46
Rheumatoid Arthritis (RA) ANA 49% NA 43 32% NA 25
Systemic Sclerosis (SSc) Centromere 20-57.8% Yes 48 NA
Topoisomerase I 17-71% Yes 48 NA
RNA polymerase III 4-20% Yes 48 NA
Fibrillarin 2-18% Yes 48 NA
Elastin 0% NA 49 20% NA 49
Collagen I 0% NA 49 20% NA 49
Collagen IV 0% NA 49 20% NA 49