3.3 Distribution of G Genotype of RVA
In this study, VP7 region analysis of 246 RAV-positive specimens revealed a large genetic diversity of circulating RAV strains. Except for 16 RVA-positive samples that could not be successfully genotyped, seven genotypes were identified during the study period, including G1, G2, G3, G4, G6, G8, and G9. Among them, G9 (46.3%, 114/246) was the most common G genotype, followed by G8 (37.4%, 92/246) and G3 (4.1%, 10/246). The prevalence of G genotypes varied over the years. Only three and four definite G genotypes were identified in 2020 and 2022, whereas seven definite G genotypes were found in 2021. G9 was the predominant genotype in 2020 (68.2%, 15/22) and 2021 (59.2%, 87/147). In contrast, G8 (68.8%, 53/77) suddenly became the most popular genotype in 2022, after being first identified in 2020 and prevalent in 2021. The second most common G genotype was G8 (25.9%, 38/147) in 2021, while G9 (15.6%, 12/77) shifted to become the second most common genotype in 2022(Figure 3A).