Exposure |
|
|
|
|
Estradiol (binary) |
|
|
Individuals of European ancestry in the UK
Biobank |
Schmitz et al. (2021) |
Estradiol levels in women |
37,461 women above/equal to the detection
limita
|
2 |
|
|
|
126,524 women below the detection limita
|
|
|
|
Estradiol levels in men |
13,367 men above/equal to the detection
limita
|
16 |
|
|
|
134,323 men below the detection limita
|
|
|
|
Estradiol (continuous) |
|
|
|
|
Estradiol levels in women |
163,985
women
(37,461 women above/equal to and 126,524 women below
the detection limita)
|
2 |
|
|
Estradiol levels in men |
147,690
men
(13,367 men above/equal to and 134,323 men below the
detection limita)
|
13 |
|
|
Total testosterone (TT) |
|
|
Individuals of European ancestry in the UK
Biobank |
Ruth et al. (2020) |
TT levels in women |
230,454 women |
254 |
|
|
TT levels in men |
194,453 men |
231 |
|
|
Bioavailable testosterone (BT) |
|
|
|
|
BT levels in women |
188,507 women |
179 |
|
|
BT levels in men |
178,782 men |
125 |
|
|
Sex hormone-binding globulin (SHBG) |
|
|
|
|
SHBG levels adjusted for BMI in women |
188,908 women |
359 |
|
|
SHBG levels adjusted for BMI in men |
180,094 men |
357 |
|
|
SHBG levels unadjusted for BMI in women |
189,473 women |
225 |
|
|
SHBG levels unadjusted for BMI in men |
180,726 men |
245 |
|
|
Outcome |
|
|
|
|
COVID-19b
|
|
|
|
|
SARS-CoV-2 infection |
74,614 cases |
NA |
European ancestry |
COVID-19 Host Genetics Initiative
data
freeze 6 (June 2021)
|
|
1,803,529 controls |
|
|
|
COVID-19 hospitalization |
14,925
cases |
NA |
European ancestry |
|
|
1,393,029 controls |
|
|
|
COVID-19 critical illness |
4,297
cases |
NA |
European ancestry |
COVID-19 Host
Genetics Initiative
data freeze 5 (January
2021)
|
|
378,521 controls |
|
|
|