Genetic instruments mapped to androgen signaling genes
To further investigate the causal effects of androgen signaling on
COVID-19 susceptibility and severity, we used three top hits
(rs112881196, rs17703883, and rs12944649) for BT levels in men and six
hits (rs112635299, rs17580, rs78081080, rs727428, rs1050541, and
rs9895413) in women as genetic instruments, respectively. These hits
were located within 1Mb of eight androgen signaling genes (as shown inTable 2 ), which were identified using the high-throughput drug
screen in the study by Samuel et al 8.