Micro-PET/CT studies of the 68Ga-HZ20 probe in
normal mice
PET images of normal KM mice showed
that the probe entered the body and was rapidly distributed with blood
circulation and metabolized by the kidney and bladder (Fig. S2A). The
maximum single-voxel standardized uptake value (SUVmax), which is the
standard nuclear medicine metric, was chosen to show the probe
accumulation in tissues or organs by measuring the maximum voxel value
in a volume of interest (organs) standardized to patient mass and
administered activity. The SUVmax showed that the probe was rapidly
cleared from the mouse heart blood pool from 0.51±0.04 to 0.15±0.04
(p=0.0004) at 60 min after injection, and the remaining probe mainly
accumulated in the kidneys at 1.3±0.16 (Fig. S2B).
Although the uptake values of the
liver (0.43±0.02) and lungs (0.43±0.03) were similar, the density in the
liver was much greater than that in the lungs, suggesting that the
uptake of probe was higher in lung tissue than in liver tissue.