We are reporting a case of toxic epidermal necrosis induced by herbal medicine in a 54-year-old woman who had been diagnosed with primary Sjogren’s syndrome for nine years and had discontinued all conventional therapies for at least one year. Approximately two weeks prior to her current admission, she developed crops of petechiae and purpuric macules on her lower extremities, which are typical symptoms of hypergammaglobulinemic purpura of Waldenström, and began taking herbal medicine. The following day, she presented to us with a high fever and new, generalized erythematous rashes over her face and trunk. She was ultimately diagnosed with toxic epidermal necrosis induced by the herbal medicine.