CONCLUSIONS
Knowledge of redox energetics of oxidoreductases is critical to understanding metabolic function and evolution. ProtReDox is intended to be a valuable tool in this regard as we and others contribute to its growth. Currently, the size of ProtReDox limits the extent to which structure-based predictive models can be trained on redox energetics. However, with further experimental investigations and as high-quality models of protein structures become readily accessible, these models should improve. This would allow more complete mapping of data structures such as the SpAN, providing a greater understanding of the evolution of redox energetics in metabolism through time.