Study criteria for DOR
It is blur to distinguish DOR from poor ovarian responder (POR), that was given the similar definition in this study The Bologna ESHRE consensus defines women as “poor ovarian responders” when at least two of the following three characteristics are present: (i) advanced maternal age (≥40 years) or any of the risk factors for POR, (ii) a previous poor ovarian response (≤3 oocytes with a conventional stimulation protocol), and (iii) an abnormal ovarian reserve test (i.e., antral follicular count (AFC) <5–7 follicles or AMH <0.5–1.1 ng/ml)[3]. Consequently, a young infertile woman with markers of poor ovarian reserve who has never undergone ART does not meet the Bologna criteria.
In this study, we define DOR more as a state of poor ovarian reserve, belonging the POSEIDON group 3 or group 4 population, a state of extreme poor ovarian function, specifically a: (i) women with ≥40 years old or any of the risk factors for poor ovarian response and/or (ii) an abnormal ovarian reserve test: antral follicular count (AFC) <5–7 follicles or anti-Müllerian hormone (AMH) <1.1 ng/ml)[10].