Tissue Biochemistry
MDA, a biomarker that indicates oxidative stress as a lipid peroxidation
product, showed a significant increase in the CIS group as compared to
the Control group (p<0.05). Intriguingly, MDA levels were
significantly higher in the RAN+CIS group than in the CIS and CIS+RAN
groups (p<0.05) (Figure 4).
SOD, CAT, and GSH are antioxidant enzymes that work to prevent damage
caused by ROS and take part in different enzymatic steps to render these
radicals harmless. SOD levels were decreased in the CIS and RAN+CIS
groups, as compared to the Control group, but increased nonsignificantly
in the CIS+RAN group (p>0.05). CAT and GSH values were
similar among groups (p>0.05) (Figure 4).