Histopathological Findings
The renal tissue in the control group exhibited a normal histological appearance (Figure 3A). In contrast, the CIS group displayed cortical and medullary tubular degenerative changes, necrosis of epithelial cells in cortical tubules, and dilatation of medullary tubules, along with caste formation observed in the lumen of some tubules (Figure 3B). Notably, the differences between the control and CIS groups were found to be statistically significant (p<0.0001).
In the RAN+CIS group, the observed histopathological changes were significantly reduced as compared to the CIS group (p<0.0001) (Figure 3C). However, degenerative changes in the tubules persisted, and the severity of tubular degeneration, especially tubular dilatation, was significantly higher in the CIS+RAN group than in the CIS group (p<0.0001) (Figure 3D). The histopathological evaluation results of the groups are presented in Figure 3E.