Histopathological Findings
The renal tissue in the control group exhibited a normal histological
appearance (Figure 3A). In contrast, the CIS group displayed cortical
and medullary tubular degenerative changes, necrosis of epithelial cells
in cortical tubules, and dilatation of medullary tubules, along with
caste formation observed in the lumen of some tubules (Figure 3B).
Notably, the differences between the control and CIS groups were found
to be statistically significant (p<0.0001).
In the RAN+CIS group, the observed histopathological changes were
significantly reduced as compared to the CIS group (p<0.0001)
(Figure 3C). However, degenerative changes in the tubules persisted, and
the severity of tubular degeneration, especially tubular dilatation, was
significantly higher in the CIS+RAN group than in the CIS group
(p<0.0001) (Figure 3D). The histopathological evaluation
results of the groups are presented in Figure 3E.