Multi-agent or compounded preparations
Multi-agent formulations contain several ingredients (at least three
ingredients). These ingredients may include an antibiotic, a local
anesthetic or topical anesthetic and a steroid to reduce inflammation.
Most formulations are used every 4-6 hours. Patients are advised to hold
the formulation in the mouth for 2-5 minutes, then spit out or swallow,
and to abstain from eating or drinking for 30 minutes after use. The
three studies that focused on multi-agent preparations and mouthwashes
have not only demonstrated their superiority over bland rinses to treat
mucositis but also alleviate pain 2122 25