Simvastatin |
S. cerevisiae BY4741 |
Introducing the synthetic
gene of monacline J; adding the acyl-donor dimethylbutyryl-S-methyl
mercaptopropionate (DMB-SMMP) into the culture medium; In situ chemical
lysis of cell wall |
55 mg/L |
(Bond and Tang 2019) |
Lovastatin |
P. pastoris GS115 |
Introducing lovastatin synthesis
gene into P. pastoris GS115; using dihydromonacolin L as a
metabolic node, dividing the synthetic pathway into upstream and
downstream modules; Co-culture strategy |
250.8 mg/L |
(Liu, Tu et al.
2018) |
|
|
Overexpressing the statins pump protein TapA (a membrane protein
that enables lovastatin to flow out of cells) |
419.0±9.5 mg/L |
(Liu,
Bai et al. 2018) |
|
A. terreus ATCC 20542 |
Inserting the antibiotic marker
hygromycin B (hyg) within the gedC gene that encodes
emodin anthrone polyketide synthase (PKS), a primary gene responsible
for initiating (+)-geodin biosynthesis to get an A. terreus
mutant strain (gedCΔ) |
113 mg/L |
(Hasan, Abd Rahim et al.
2019) |
|
A. terreus EM19
|
Inducing A. terreus
GD13 for three cycles |
1424 mg/L |
(Kaur, Kaur et al.
2009) |
|
Fusarium sp. Alaa-20 |
Enhancing mutagenesis induction and
three successive gene recombination of Fusarium sp. Alaa-20 |
52.1 mg/gds |
(El-Bondkly, El-Gendy et al. 2021) |
Pravastatin |
Streptomyces sp. Y-110 |
Adding compactin to the
medium intermittently |
1000 mg/L |
(Park, Lee et al.
2003) |
|
P. chrysogenum DS50662 |
Introducing the compactin pathway into
the beta-lactam-negative P. chrysogenum DS50662; A evolved
cytochrome P450 (P450 or CYP) were used to catalyze the final compactin
hydroxylation step |
6 g/L |
(McLean, Hans et al. 2015) |