Spectrum activity of faropenem:
Gram-positive bacteria : Faropenem is highly potent againstS. pneumoniae ,11Upchurch J, Rosemore M, Tosiello R,et al . Randomized double-blind study comparing 7- and 10-day regimens of faropenem medoxomil with a 10-day cefuroxime axetil regimen for treatment of acute bacterial sinusitis. Otolaryngol Head Neck Surg. 2006;135(4):511–517. and in vitro activity has been noted against many methicillin-sensitive and methicillin-resistant strains of S. aureus and coagulase-negative Staphylococci.
Gram-negative bacteria : Faropenem has good in vitro activity against E. coli and Klebsiella spp. with ESBLs, including the CTX-M types.22Shazad Mushtaq and others, Activity of faropenem against cephalosporin-resistant Enterobacteriaceae, Journal of Antimicrobial Chemotherapy , Volume 59, Issue 5, May 2007, Pages 1025–1030, https://doi.org/10.1093/jac/dkm063 Furthermore, it has significant activity against the common respiratory pathogens,H. influenzae and M. catarrhalis .
Anaerobes : Against Clostridium perfringens , faropenem is as active as metronidazole and clindamycin. Faropenem also has activity against Peptostreptococci and B. fragilis .
As depicted in Table 1, faropenem exhibited better inhibitory potential compared to other antimicrobials like cefuroxime and Co-amoxiclav.
Table 1. The better activity of faropenem compared to other antimicrobials33Wexler HM, Molitoris D, St John S, et al.In vitro activities of faropenem against 579 strains of anaerobic bacteria. Antimicrob Agents Chemother. 2002;46(11):3669–3675,44Woodcock JM, Andrews JM, Brenwald NP, et al. The in-vitro activity of faropenem, a novel oral penem. J Antimicrob Chemother. 1997;39(1):35–43.