Spectrum activity of faropenem:
Gram-positive bacteria : Faropenem is highly potent againstS. pneumoniae ,11Upchurch J, Rosemore M, Tosiello R,et al . Randomized double-blind study comparing 7- and 10-day
regimens of faropenem medoxomil with a 10-day cefuroxime axetil
regimen for treatment of acute bacterial sinusitis. Otolaryngol Head
Neck Surg. 2006;135(4):511–517. and in vitro activity has been
noted against many methicillin-sensitive and methicillin-resistant
strains of S. aureus and coagulase-negative Staphylococci.
Gram-negative bacteria : Faropenem has good in vitro activity
against E. coli and Klebsiella spp. with ESBLs,
including the CTX-M types.22Shazad Mushtaq and others,
Activity of faropenem against cephalosporin-resistant
Enterobacteriaceae, Journal of Antimicrobial Chemotherapy ,
Volume 59, Issue 5, May 2007, Pages
1025–1030, https://doi.org/10.1093/jac/dkm063 Furthermore,
it has significant activity against the common respiratory pathogens,H. influenzae and M. catarrhalis .
Anaerobes : Against Clostridium perfringens , faropenem is
as active as metronidazole and clindamycin. Faropenem also has activity
against Peptostreptococci and B. fragilis .
As depicted in Table 1, faropenem exhibited better
inhibitory potential compared to other antimicrobials like cefuroxime
and Co-amoxiclav.
Table 1. The better activity of faropenem compared to other
antimicrobials33Wexler HM, Molitoris D, St John S, et al.In vitro activities of faropenem against 579 strains of
anaerobic bacteria. Antimicrob Agents Chemother.
2002;46(11):3669–3675,44Woodcock JM, Andrews JM, Brenwald
NP, et al. The in-vitro activity of faropenem, a novel
oral penem. J Antimicrob Chemother. 1997;39(1):35–43.