Figure 2. Treatments with CP11 result in larger restored neuromuscular responses. A. Outline of experimental scheme. Mice were treated with CP11 or vehicle daily, five days per week for two weeks, beginning on the third day following sciatic nerve transection and repair. After two more weeks, neuromuscular reinnervation was tested. B. Examples of maximal amplitude M responses (Mmax) recorded four weeks after sciatic nerve transection and repair from a vehicle-treated (top) and a CP11-treated (bottom) mouse. C. Mean (+ SEM) amplitudes of Mmax recorded from tibialis anterior (TA) and lateral gastrocnemius (LG) in vehicle-treated and CP11-treated mice, either via i.p. injection or oral gavage, four weeks after sciatic nerve transection and repair. Significance of differences between CP11-treated and vehicle-treated mice was evaluated for each muscle using ANOVA and post hoc paired testing. P values are shown to indicate the significance of differences in paired comparisons.