Statistical analysis
For the statistical evaluations of various factors, the SPSS for Windows statistical software suite (SPSS Inc., Chicago, IL, USA, 2016) was employed. Data from all parameters were collected from multiple independent set as well as replicated from a single set of experiments. The Kolmogorov-Smirnov test was used to examine the data distribution pattern. Students t’ test analysis and multiple comparison ANOVA tests were used to evaluate the baseline continuous variables and the results of the analyses. The level of significance were denoted within the 95% confidence limit and represented as p<0.001 to p<0.05.