TABLE 3 Key Demographic and Clinical Data for Patients Receiving Apixaban Prior to Undergoing Heart Transplantation.
Patient Sex Age
(years) Pre-Transplant Anatomy Weight (kg) UNOS Listing Status Apixaban Apixaban Apixaban Level Prior to OR Arrival (ng/mL) Time from last Dose to OR Arrival (hh:mm) Chest Tube Output Chest Tube Output
Dose Length of Therapy (Days) Indication First 2 hours
(mL/kg/hr) First 4 hours (mL/kg/hr)
1 Female 5.6 HLHS palliated to Fontan 16.4 1A 1.25mg 193 Prophylaxis LMWH: 0.7 20:38 9.8 13.1
2 Male 16.9 Tetralogy of Fallot, RV-PA conduit 82.2 1A 5mg 12 Therapeutic 17:06 0.8 0.6
3 Male 13.5 Dilated Cardiomyopathy 67.9 1B 5mg 26 Prophylaxis 17:36 0.5 0.4
4 Female 15.0 L-TGA with PA, double switch, RV-PA conduit 52.6 1A 2.5mg 51 Prophylaxis LMWH: 1.67 23:51 2.7 1.8
5 Female 11.2 Dilated Cardiomyopathy 73.5 1A 5mg 72 Prophylaxis 31:15 0.3 0.2
6† Female 7.5 HLHS, Glenn with BTT shunt 15.7 1A 1.25mg 160 Prophylaxis 28.4 14:27 1.7 1.9
7 Female 2.9 L-TGA with PA, Mustard and Rastelli 13.4 1A 1.25mg 14 Prophylaxis 27 25:36 7.9 6.0
8 Male 4.9 CAVC, DORV and PA, RV-PA conduit, Mitral Valve Replacement 14.2 1A 1.25mg 321 Therapeutic 36.9 24:43 1.9 1.3
9 Female 3.3 Dilated Cardiomyopathy 12.9 1A 1.25mg 243 Prophylaxis 44.5 15:51 0.5 0.5
10 Male 19.1 PA/IVS Glenn, Melody in RVOT 48.9 1A 5mg 189 Prophylaxis 28 27:34 2.0 2.5
11 Female 13.1 Transitional AVC with common atria, Mustard caval baffle. HM3 67.2 1A 5mg 146 VAD Prophylaxis 54.2 30:06 1.1 0.9
12* Male 24.8 AVC with PA, Fontan. HM3 46.9 2 3.75mg 189 VAD Prophylaxis 22:46 3.9 2.7
13 Male 0.8 HLHS, Sano 6.76 1A 0.625mg 159 Prophylaxis 73.2 15:36 14.3 8.4
14† Male 17.5 Dilated Cardiomyopathy. HM3 101.5 1A 7.5mg 86 VAD Prophylaxis 37 14:43 1.6 1.4
15 Male 6.6 Unbalanced RV-dominant AVC with PA, Hemifontan 15.1 1B 1.25mg 123 Prophylaxis <23.0 22:47 9.9 6.6
16 Male 16.0 TGA with TA, Fontan 91.7 1A 5mg 15 Prophylaxis 81.5 33:49 0.7 0.6
17† Male 15.4 Unbalanced CAVC, Kawashima 56.1 1A 2.5mg 62 Prophylaxis 35 27:24 9.9 10.9
18 Male 15.6 Restrictive Cardiomyopathy 64.2 1A 2.5mg 4 Prophylaxis 82.8 25:39 0.9 0.6
19 Female 15.0 Dilated Cardiomyopathy 46.3 1A 3.75mg 113 Prophylaxis 26.8 39:11 2.6 2.6
*Required post-operative intervention for bleeding thought secondary to complication from trancatheter stent placement. †Mortality Post-transplant, none due to bleeding-related complications Bolded values met definitions of significant bleeding UNOS, United Network for Organ Sharing; HLHS, Hypoplastic Left-Heart Syndrome; RV, right ventricle; PA, pulmonary artery; L-TGA, L-looped transposition of the great arteries; BTT, Blalock-Tausig Thomas;, CAV, complete atrioventricular canal; DORV, double outlet right ventricle: PA/IVS, pulmonary atresia with intact ventricular septum; RVOT, right ventricular outflow tract; HM3, Heartmate 3; TA, tricuspid atresia; LMWH, low molecular weight heparin. *Required post-operative intervention for bleeding thought secondary to complication from trancatheter stent placement. †Mortality Post-transplant, none due to bleeding-related complications Bolded values met definitions of significant bleeding UNOS, United Network for Organ Sharing; HLHS, Hypoplastic Left-Heart Syndrome; RV, right ventricle; PA, pulmonary artery; L-TGA, L-looped transposition of the great arteries; BTT, Blalock-Tausig Thomas;, CAV, complete atrioventricular canal; DORV, double outlet right ventricle: PA/IVS, pulmonary atresia with intact ventricular septum; RVOT, right ventricular outflow tract; HM3, Heartmate 3; TA, tricuspid atresia; LMWH, low molecular weight heparin. *Required post-operative intervention for bleeding thought secondary to complication from trancatheter stent placement. †Mortality Post-transplant, none due to bleeding-related complications Bolded values met definitions of significant bleeding UNOS, United Network for Organ Sharing; HLHS, Hypoplastic Left-Heart Syndrome; RV, right ventricle; PA, pulmonary artery; L-TGA, L-looped transposition of the great arteries; BTT, Blalock-Tausig Thomas;, CAV, complete atrioventricular canal; DORV, double outlet right ventricle: PA/IVS, pulmonary atresia with intact ventricular septum; RVOT, right ventricular outflow tract; HM3, Heartmate 3; TA, tricuspid atresia; LMWH, low molecular weight heparin. *Required post-operative intervention for bleeding thought secondary to complication from trancatheter stent placement. †Mortality Post-transplant, none due to bleeding-related complications Bolded values met definitions of significant bleeding UNOS, United Network for Organ Sharing; HLHS, Hypoplastic Left-Heart Syndrome; RV, right ventricle; PA, pulmonary artery; L-TGA, L-looped transposition of the great arteries; BTT, Blalock-Tausig Thomas;, CAV, complete atrioventricular canal; DORV, double outlet right ventricle: PA/IVS, pulmonary atresia with intact ventricular septum; RVOT, right ventricular outflow tract; HM3, Heartmate 3; TA, tricuspid atresia; LMWH, low molecular weight heparin. *Required post-operative intervention for bleeding thought secondary to complication from trancatheter stent placement. †Mortality Post-transplant, none due to bleeding-related complications Bolded values met definitions of significant bleeding UNOS, United Network for Organ Sharing; HLHS, Hypoplastic Left-Heart Syndrome; RV, right ventricle; PA, pulmonary artery; L-TGA, L-looped transposition of the great arteries; BTT, Blalock-Tausig Thomas;, CAV, complete atrioventricular canal; DORV, double outlet right ventricle: PA/IVS, pulmonary atresia with intact ventricular septum; RVOT, right ventricular outflow tract; HM3, Heartmate 3; TA, tricuspid atresia; LMWH, low molecular weight heparin. *Required post-operative intervention for bleeding thought secondary to complication from trancatheter stent placement. †Mortality Post-transplant, none due to bleeding-related complications Bolded values met definitions of significant bleeding UNOS, United Network for Organ Sharing; HLHS, Hypoplastic Left-Heart Syndrome; RV, right ventricle; PA, pulmonary artery; L-TGA, L-looped transposition of the great arteries; BTT, Blalock-Tausig Thomas;, CAV, complete atrioventricular canal; DORV, double outlet right ventricle: PA/IVS, pulmonary atresia with intact ventricular septum; RVOT, right ventricular outflow tract; HM3, Heartmate 3; TA, tricuspid atresia; LMWH, low molecular weight heparin. *Required post-operative intervention for bleeding thought secondary to complication from trancatheter stent placement. †Mortality Post-transplant, none due to bleeding-related complications Bolded values met definitions of significant bleeding UNOS, United Network for Organ Sharing; HLHS, Hypoplastic Left-Heart Syndrome; RV, right ventricle; PA, pulmonary artery; L-TGA, L-looped transposition of the great arteries; BTT, Blalock-Tausig Thomas;, CAV, complete atrioventricular canal; DORV, double outlet right ventricle: PA/IVS, pulmonary atresia with intact ventricular septum; RVOT, right ventricular outflow tract; HM3, Heartmate 3; TA, tricuspid atresia; LMWH, low molecular weight heparin. *Required post-operative intervention for bleeding thought secondary to complication from trancatheter stent placement. †Mortality Post-transplant, none due to bleeding-related complications Bolded values met definitions of significant bleeding UNOS, United Network for Organ Sharing; HLHS, Hypoplastic Left-Heart Syndrome; RV, right ventricle; PA, pulmonary artery; L-TGA, L-looped transposition of the great arteries; BTT, Blalock-Tausig Thomas;, CAV, complete atrioventricular canal; DORV, double outlet right ventricle: PA/IVS, pulmonary atresia with intact ventricular septum; RVOT, right ventricular outflow tract; HM3, Heartmate 3; TA, tricuspid atresia; LMWH, low molecular weight heparin. *Required post-operative intervention for bleeding thought secondary to complication from trancatheter stent placement. †Mortality Post-transplant, none due to bleeding-related complications Bolded values met definitions of significant bleeding UNOS, United Network for Organ Sharing; HLHS, Hypoplastic Left-Heart Syndrome; RV, right ventricle; PA, pulmonary artery; L-TGA, L-looped transposition of the great arteries; BTT, Blalock-Tausig Thomas;, CAV, complete atrioventricular canal; DORV, double outlet right ventricle: PA/IVS, pulmonary atresia with intact ventricular septum; RVOT, right ventricular outflow tract; HM3, Heartmate 3; TA, tricuspid atresia; LMWH, low molecular weight heparin. *Required post-operative intervention for bleeding thought secondary to complication from trancatheter stent placement. †Mortality Post-transplant, none due to bleeding-related complications Bolded values met definitions of significant bleeding UNOS, United Network for Organ Sharing; HLHS, Hypoplastic Left-Heart Syndrome; RV, right ventricle; PA, pulmonary artery; L-TGA, L-looped transposition of the great arteries; BTT, Blalock-Tausig Thomas;, CAV, complete atrioventricular canal; DORV, double outlet right ventricle: PA/IVS, pulmonary atresia with intact ventricular septum; RVOT, right ventricular outflow tract; HM3, Heartmate 3; TA, tricuspid atresia; LMWH, low molecular weight heparin. *Required post-operative intervention for bleeding thought secondary to complication from trancatheter stent placement. †Mortality Post-transplant, none due to bleeding-related complications Bolded values met definitions of significant bleeding UNOS, United Network for Organ Sharing; HLHS, Hypoplastic Left-Heart Syndrome; RV, right ventricle; PA, pulmonary artery; L-TGA, L-looped transposition of the great arteries; BTT, Blalock-Tausig Thomas;, CAV, complete atrioventricular canal; DORV, double outlet right ventricle: PA/IVS, pulmonary atresia with intact ventricular septum; RVOT, right ventricular outflow tract; HM3, Heartmate 3; TA, tricuspid atresia; LMWH, low molecular weight heparin. *Required post-operative intervention for bleeding thought secondary to complication from trancatheter stent placement. †Mortality Post-transplant, none due to bleeding-related complications Bolded values met definitions of significant bleeding UNOS, United Network for Organ Sharing; HLHS, Hypoplastic Left-Heart Syndrome; RV, right ventricle; PA, pulmonary artery; L-TGA, L-looped transposition of the great arteries; BTT, Blalock-Tausig Thomas;, CAV, complete atrioventricular canal; DORV, double outlet right ventricle: PA/IVS, pulmonary atresia with intact ventricular septum; RVOT, right ventricular outflow tract; HM3, Heartmate 3; TA, tricuspid atresia; LMWH, low molecular weight heparin. *Required post-operative intervention for bleeding thought secondary to complication from trancatheter stent placement. †Mortality Post-transplant, none due to bleeding-related complications Bolded values met definitions of significant bleeding UNOS, United Network for Organ Sharing; HLHS, Hypoplastic Left-Heart Syndrome; RV, right ventricle; PA, pulmonary artery; L-TGA, L-looped transposition of the great arteries; BTT, Blalock-Tausig Thomas;, CAV, complete atrioventricular canal; DORV, double outlet right ventricle: PA/IVS, pulmonary atresia with intact ventricular septum; RVOT, right ventricular outflow tract; HM3, Heartmate 3; TA, tricuspid atresia; LMWH, low molecular weight heparin.