TABLE 2 Apixaban Dosing, Monitoring, and Peri-operative Management TABLE 2 Apixaban Dosing, Monitoring, and Peri-operative Management TABLE 2 Apixaban Dosing, Monitoring, and Peri-operative Management
Length of Apixaban Therapy Pre-Transplant (days) Length of Apixaban Therapy Pre-Transplant (days) 114.6 (38.5, 174.5)*
Prophylaxis Indication (N%) Prophylaxis Indication (N%) 68%
Concomitant Aspirin use (N%) Concomitant Aspirin use (N%) 21%
Time from Last Dose to OR Arrival (hours) Time from Last Dose to OR Arrival (hours) 23.2 (17.2, 27.5)*
Pre-OR Apixaban Level (ng/mL) Pre-OR Apixaban Level (ng/mL) 37 (28.3, 59)*
Time from Last Level to OR Arrival (hours) Time from Last Level to OR Arrival (hours) 6.2 (4.8, 8.4)*
Chest Tube Out (mL/kg/hr) Chest Tube Out (mL/kg/hr)
First 2 Post-Operative Hours 1.9 (0.9, 5.9)*
First 4 Post-Operative Hours 1.8 (0.6, 4.5)*
Patients Requiring Re-Operation for Bleeding (N%) Patients Requiring Re-Operation for Bleeding (N%) 5%
Significant Post-Operative Bleeding (N%) Significant Post-Operative Bleeding (N%) 32%
Operating Room, OR. *Median values with 25th and 75th interquartile range. Operating Room, OR. *Median values with 25th and 75th interquartile range. Operating Room, OR. *Median values with 25th and 75th interquartile range.