7.2 - GILZ and viral infections
To date, no studies have demonstrated the pro-resolutive effect of GILZ
during viral infections. In fact, research has shown that GILZ binds to
STAT1 and hinders its translocation to the nucleus, thereby reducing the
expression of type I interferon-induced genes (Nataraja et al., 2022).
This suggests that GILZ may have a detrimental impact on the host during
certain viral infections. Additionally, studies have revealed that the
infectious bursal disease virus (IBDV) thwarts the ubiquitination and
degradation of GILZ in the cytoplasm through the viral protein VP4,
leading to the inhibition of type I interferon production in
vitro . Knockdown of GILZ using siRNA significantly impeded IBDV
replication (He et al., 2018; Li et al., 2013). Further investigations
are required to establish the precise role of GILZ during viral
infections.