Mediator Pathogen class Overall effects
LXA4 Bacteria In general, beneficial effects against different types of bacteria. Administration of LXA4 is associated with diminished production of pro-inflammatory mediators and enhanced efficacy of bacterial clearance when administered with antibiotics.
Resolvins Virus Overall, Resolvins display anti-inflammatory and protection from tissue damage without affecting viral load.
Bacteria Robust evidence demonstrates that different types of resolvins decrease inflammation, enhance bacterial clearance and increase efferocytosis.
Maresins Bacteria Despite little data, evidence suggests pro-resolutive effects, such as decreased inflammation and bacterial burden.
Protectins Bacteria Overall, administration of PD1 is associated with decreased bacterial burden and increased production of anti-inflammatory mediators.
Virus PD1 administration decreased both inflammation and viral loads against different viruses, such as RSV, HSV, H1N1 and H5N1.
GILZ Bacteria Evidence points towards to pro-resolutive effects depending on the host cell and bacteria type.
AnxA1 Bacteria In most of the studies, AnxA1 and Ac2-26 were associated with diminished inflammation and enhanced bacterial clearance.
Virus Accelerated resolution and decreased inflammation of endogenous AnxA1 and Ac2-26 treatment against arbovirus infections.
Angio (1-7) Virus Ang-(1-7) reduces exacerbated inflammatory response, increases apoptosis and efferocytosis of neutrophils in the lung, reduces lung damage and reduces Influenza A virus in the lung.
Bacteria Ang-(1-7) prevents sepsis, bacterial burden in the lung, recovers ability of neutrophils to phagocytize, decreases macrophage polarization towards the M1 and promoted it to the M2 and controls exacerbated inflammatory response.