2.1 - Resolvin D (RvD), E (RvE) and T (RvT) series
Resolvins are potent mediators that promote resolution of inflammation
and are synthesized from the lipids docosahexaenoic acid (DHA),
eicosapentaenoic acid (EPA), and n-3 docosapentaenoic acid (n-3DPA)
(Serhan and Levy, 2018). These pro-resolution molecules are synthesized
in a coordinated manner by macrophages and neutrophils to counteract
inflammation and promote resolution in the affected tissue. Resolvins
exert their actions by binding to different membrane receptors, such as
FPR2, ERV1, DRV1, and DRV2, expressed by diverse types of cells (Chiang
and Serhan, 2017).