3.2 - Maresins and viral infections
Limited data is currently available regarding the role of maresins during viral infections. In the context of SARS-CoV-2 infection, it has been observed that the levels of maresin-1 and maresin-2 were significantly higher in the serum of severe COVID-19 patients compared to healthy volunteers (Regidor et al., 2021). However, these lipids were not detected in the bronchoalveolar lavage (BAL) fluid of COVID-19 patients, although an increase in other specialized pro-resolving mediators (SPMs) was observed (Archabault et al., 2021). Additionally, in the case of respiratory syncytial virus (RSV) infection, maresin-1 has shown promising effects. It was found that maresin-1 reduced inflammation, viral transcripts, and increased the production of IFN-β during RSV infection by binding to the LGR6 receptor (Krishnamoorthy et al., 2023). However, more comprehensive studies are needed to further investigate the potential of maresins in experimental viral infections and to understand better their role in viral pathogenesis.