2.1 - Resolvin D (RvD), E (RvE) and T (RvT) series
Resolvins are potent mediators that promote resolution of inflammation and are synthesized from the lipids docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and n-3 docosapentaenoic acid (n-3DPA) (Serhan and Levy, 2018). These pro-resolution molecules are synthesized in a coordinated manner by macrophages and neutrophils to counteract inflammation and promote resolution in the affected tissue. Resolvins exert their actions by binding to different membrane receptors, such as FPR2, ERV1, DRV1, and DRV2, expressed by diverse types of cells (Chiang and Serhan, 2017).