Author Contributions
G. Augello, M. Arbitrio, L.G., M.R.E., V.D.S. and M. Cervello designed the research and wrote the manuscript; G. Augello, M. Arbitrio, F. Scionti, D.C., R.C., C.L., F.D.G. and N.S. performed the research; G. Agapito, M. Cervello and G. Augello analyzed the data; L.G., G.B., M.R., F.V., F. Spinnato, M. Affronti, A. Seidita collected samples and clinical data; P. Tagliaferri, P. Tassone, M.S., M. Catanzaro and G.M. critically revised the work. G. Augello, M. Arbitrio and M. Cervello conceived and edited the manuscript. All authors have read and agreed to the published version of the manuscript.