Statistical analysis
Normally distributed continuous variables were expressed as mean ± SD, and the differences between the two groups were assessed with the Mann Whitney U test.
DMET analysis of frequencies was calculated using Fisher’s exact test and Bonferroni’s correction for multiple comparisons using the DMET-Analyzer tool.26 In all analyses, a p-value < 0.05 was considered statistically significant. ADME genotyping calls from the intensity array were performed with DMET Console software (version 1.1, ThermoFisher Scientific, Waltham, MA, USA). All alleles were tested for Hardy-Weinberg equilibrium. Genotypes with a call rate ≤ 96%, a high rate of “possible rare allele”/“no call,” and a concordance of 100% were excluded from further analysis.