Hermansky-Pudlak Syndrome Chediak-Higashi Syndrome (CHS)
Oculocutaneous albinism Present Present
Cytoplasmic granules in platelets and neutrophils Always absent Characteristic finding
Intellectual disability/ Neurological findings May or may not be present Present in all
Hepatosplenomegaly May or may not be present Maybe present
Hemophagocytic lympohistiocytosis May or may not be present Also called the accelerated phase of CHS- develops in 85% of patients