Conclusion
PD is a neurodegenerative condition that mainly impacts the motor system. Dopamine-producing cells in the substantia nigra gradually start to disappear in this condition. Small non-coding RNA molecules known as miRNAs are essential in the control of gene expression. Studies have demonstrated that miRNAs play a role in the development of PD. In particular, several studies have investigated the potential of serum miRNAs as biomarkers for PD. miR-221 has been suggested to play a role in the pathogenesis of PD. Several studies have investigated the function of miR-221 in PD. For example, one study identified miR-221 as a promising non-invasive biomarker for PD, with a moderate to good predictive power for the disease. These findings suggest that miR-221 plays a crucial role in promoting neuronal survival and protecting against oxidative stress in PD. Therefore, targeting miR-221 may represent a potential intervention strategy for PD patients. By increasing the expression of miR-221, it may be possible to enhance neuronal survival and protect against oxidative stress, which are key factors in the pathogenesis of PD. However, further research is needed to fully understand the therapeutic potential of targeting miR-221 in PD.