REFERENCES
Aldrich, A., & Kielian, T. (2011). Central nervous system fibrosis is
associated with fibrocyte-like infiltrates. Am J Pathol, 179 (6),
2952-2962. doi:10.1016/j.ajpath.2011.08.036
Baik, S. H., Selvaraji, S., Fann, D. Y., Poh, L., Jo, D. G., Herr, D.
R., … Arumugam, T. V. (2021). Hippocampal transcriptome profiling
reveals common disease pathways in chronic hypoperfusion and aging.Aging (Albany NY), 13 (11), 14651-14674. doi:10.18632/aging.203123
Batterman, K. V., Cabrera, P. E., Moore, T. L., & Rosene, D. L. (2021).
T Cells Actively Infiltrate the White Matter of the Aging Monkey Brain
in Relation to Increased Microglial Reactivity and Cognitive Decline.Front Immunol, 12 , 607691. doi:10.3389/fimmu.2021.607691
Bowman, G. L., Dayon, L., Kirkland, R., Wojcik, J., Peyratout, G.,
Severin, I. C., … Popp, J. (2018). Blood-brain barrier breakdown,
neuroinflammation, and cognitive decline in older adults.Alzheimers Dement, 14 (12), 1640-1650.
doi:10.1016/j.jalz.2018.06.2857
Bozoki, A., Giordani, B., Heidebrink, J. L., Berent, S., & Foster, N.
L. (2001). Mild cognitive impairments predict dementia in nondemented
elderly patients with memory loss. Archives of Neurology, 58 (3),
411-416. Retrieved from
https://www.ncbi.nlm.nih.gov/pubmed/11255444
Chan, C. T., Sobey, C. G., Lieu, M., Ferens, D., Kett, M. M., Diep, H.,
… Drummond, G. R. (2015). Obligatory Role for B Cells in the
Development of Angiotensin II-Dependent Hypertension.Hypertension, 66 (5), 1023-1033.
doi:10.1161/HYPERTENSIONAHA.115.05779
Chrissobolis, S., Drummond, G. R., Faraci, F. M., & Sobey, C. G.
(2014). Chronic aldosterone administration causes Nox2-mediated
increases in reactive oxygen species production and endothelial
dysfunction in the cerebral circulation. J Hypertens, 32 (9),
1815-1821. doi:10.1097/HJH.0000000000000259
Csiszar, A., Tucsek, Z., Toth, P., Sosnowska, D., Gautam, T., Koller,
A., … Ungvari, Z. (2013). Synergistic effects of hypertension and
aging on cognitive function and hippocampal expression of genes involved
in beta-amyloid generation and Alzheimer’s disease. Am J Physiol
Heart Circ Physiol, 305 (8), H1120-1130. doi:10.1152/ajpheart.00288.2013
Dinh, Q. N., Vinh, A., Kim, H. A., Saini, N., Broughton, B. R. S.,
Chrissobolis, S., … Sobey, C. G. (2021). Aldosterone-induced
hypertension is sex-dependent, mediated by T cells and sensitive to GPER
activation. Cardiovasc Res, 117 (3), 960-970.
doi:10.1093/cvr/cvaa075
Dinh, Q. N., Young, M. J., Evans, M. A., Drummond, G. R., Sobey, C. G.,
& Chrissobolis, S. (2016). Aldosterone-induced oxidative stress and
inflammation in the brain are mediated by the endothelial cell
mineralocorticoid receptor. Brain Res, 1637 , 146-153.
doi:10.1016/j.brainres.2016.02.034
Don-Doncow, N., Vanherle, L., Zhang, Y., & Meissner, A. (2019). T-Cell
Accumulation in the Hypertensive Brain: A Role for
Sphingosine-1-Phosphate-Mediated Chemotaxis. Int J Mol Sci,
20 (3)doi:10.3390/ijms20030537
Drummond, G. R., Vinh, A., Guzik, T. J., & Sobey, C. G. (2019). Immune
mechanisms of hypertension. Nat Rev Immunol, 19 (8), 517-532.
doi:10.1038/s41577-019-0160-5
Faraco, G., Sugiyama, Y., Lane, D., Garcia-Bonilla, L., Chang, H.,
Santisteban, M. M., … Iadecola, C. (2016). Perivascular
macrophages mediate the neurovascular and cognitive dysfunction
associated with hypertension. J Clin Invest, 126 (12), 4674-4689.
doi:10.1172/JCI86950
Foulquier, S., Namsolleck, P., Van Hagen, B. T., Milanova, I., Post, M.
J., Blankesteijn, W. M., … Unger, T. (2018). Hypertension-induced
cognitive impairment: insights from prolonged angiotensin II infusion in
mice. Hypertens Res, 41 (10), 817-827.
doi:10.1038/s41440-018-0090-9
Fu, Q., Wu, J., Zhou, X. Y., Ji, M. H., Mao, Q. H., Li, Q., …
Yang, J. J. (2019). NLRP3/Caspase-1 Pathway-Induced Pyroptosis Mediated
Cognitive Deficits in a Mouse Model of Sepsis-Associated Encephalopathy.Inflammation, 42 (1), 306-318. doi:10.1007/s10753-018-0894-4
Fu, Y., & Yan, Y. (2018). Emerging Role of Immunity in Cerebral Small
Vessel Disease. Front Immunol, 9 , 67.
doi:10.3389/fimmu.2018.00067
Group, S. M. I. f. t. S. R., Williamson, J. D., Pajewski, N. M., Auchus,
A. P., Bryan, R. N., Chelune, G., … Wright, C. B. (2019). Effect
of Intensive vs Standard Blood Pressure Control on Probable Dementia: A
Randomized Clinical Trial. JAMA, 321 (6), 553-561.
doi:10.1001/jama.2018.21442
Guzik, T. J., Hoch, N. E., Brown, K. A., McCann, L. A., Rahman, A.,
Dikalov, S., … Harrison, D. G. (2007). Role of the T cell in the
genesis of angiotensin II induced hypertension and vascular dysfunction.Journal of Experimental Medicine, 204 (10), 2449-2460.
doi:10.1084/jem.20070657
Hammer, M., Echtenachter, B., Weighardt, H., Jozefowski, K., Rose-John,
S., Mannel, D. N., … Lang, R. (2010). Increased inflammation and
lethality of Dusp1-/- mice in polymicrobial peritonitis models.Immunology, 131 (3), 395-404. doi:10.1111/j.1365-2567.2010.03313.x
Iadecola, C., Yaffe, K., Biller, J., Bratzke, L. C., Faraci, F. M.,
Gorelick, P. B., … Stroke, C. (2016). Impact of Hypertension on
Cognitive Function: A Scientific Statement From the American Heart
Association. Hypertension, 68 (6), e67-e94.
doi:10.1161/HYP.0000000000000053
Iulita, M. F., Vallerand, D., Beauvillier, M., Haupert, N., C, A. U.,
Gagne, A., … Girouard, H. (2018). Differential effect of
angiotensin II and blood pressure on hippocampal inflammation in mice.J Neuroinflammation, 15 (1), 62. doi:10.1186/s12974-018-1090-z
Jalal, F. Y., Yang, Y., Thompson, J. F., Roitbak, T., & Rosenberg, G.
A. (2015). Hypoxia-induced neuroinflammatory white-matter injury reduced
by minocycline in SHR/SP. J Cereb Blood Flow Metab, 35 (7),
1145-1153. doi:10.1038/jcbfm.2015.21
Jennings, J. R., & Zanstra, Y. (2009). Is the brain the essential in
hypertension? Neuroimage, 47 (3), 914-921.
doi:10.1016/j.neuroimage.2009.04.072
Krishnan, S. M., Ling, Y. H., Huuskes, B. M., Ferens, D. M., Saini, N.,
Chan, C. T., … Vinh, A. (2019). Pharmacological inhibition of the
NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction
in salt-sensitive hypertension. Cardiovasc Res, 115 (4), 776-787.
doi:10.1093/cvr/cvy252
Laurent, C., Dorothee, G., Hunot, S., Martin, E., Monnet, Y., Duchamp,
M., … Blum, D. (2017). Hippocampal T cell infiltration promotes
neuroinflammation and cognitive decline in a mouse model of tauopathy.Brain, 140 (1), 184-200. doi:10.1093/brain/aww270
Levine, D. A., Galecki, A. T., Langa, K. M., Unverzagt, F. W., Kabeto,
M. U., Giordani, B., … Wadley, V. G. (2019). Blood Pressure and
Cognitive Decline Over 8 Years in Middle-Aged and Older Black and White
Americans. Hypertension, 73 (2), 310-318.
doi:10.1161/HYPERTENSIONAHA.118.12062
Li, M., Li, Y., Zuo, L., Hu, W., & Jiang, T. (2021). Increase of
blood-brain barrier leakage is related to cognitive decline in vascular
mild cognitive impairment. BMC Neurol, 21 (1), 159.
doi:10.1186/s12883-021-02189-6
Lueptow, L. M. (2017). Novel Object Recognition Test for the
Investigation of Learning and Memory in Mice. J Vis
Exp (126)doi:10.3791/55718
Machhi, J., Yeapuri, P., Lu, Y., Foster, E., Chikhale, R., Herskovitz,
J., … Gendelman, H. E. (2021). CD4+ effector T cells accelerate
Alzheimer’s disease in mice. J Neuroinflammation, 18 (1), 272.
doi:10.1186/s12974-021-02308-7
Mills, K. T., Bundy, J. D., Kelly, T. N., Reed, J. E., Kearney, P. M.,
Reynolds, K., … He, J. (2016). Global Disparities of Hypertension
Prevalence and Control: A Systematic Analysis of Population-Based
Studies From 90 Countries. Circulation, 134 (6), 441-450.
doi:10.1161/CIRCULATIONAHA.115.018912
Muela, H. C., Costa-Hong, V. A., Yassuda, M. S., Moraes, N. C., Memoria,
C. M., Machado, M. F., … Bortolotto, L. A. (2017). Hypertension
Severity Is Associated With Impaired Cognitive Performance. J Am
Heart Assoc, 6 (1)doi:10.1161/JAHA.116.004579
Nation, D. A., Sweeney, M. D., Montagne, A., Sagare, A. P., D’Orazio, L.
M., Pachicano, M., … Zlokovic, B. V. (2019). Blood-brain barrier
breakdown is an early biomarker of human cognitive dysfunction.Nat Med, 25 (2), 270-276. doi:10.1038/s41591-018-0297-y
Ni, P., Dong, H., Wang, Y., Zhou, Q., Xu, M., Qian, Y., & Sun, J.
(2018). IL-17A contributes to perioperative neurocognitive disorders
through blood-brain barrier disruption in aged mice. J
Neuroinflammation, 15 (1), 332. doi:10.1186/s12974-018-1374-3
Ou, Y. N., Tan, C. C., Shen, X. N., Xu, W., Hou, X. H., Dong, Q.,
… Yu, J. T. (2020). Blood Pressure and Risks of Cognitive
Impairment and Dementia: A Systematic Review and Meta-Analysis of 209
Prospective Studies. Hypertension, 76 (1), 217-225.
doi:10.1161/HYPERTENSIONAHA.120.14993
Plath, N., Ohana, O., Dammermann, B., Errington, M. L., Schmitz, D.,
Gross, C., … Kuhl, D. (2006). Arc/Arg3.1 is essential for the
consolidation of synaptic plasticity and memories. Neuron, 52 (3),
437-444. doi:10.1016/j.neuron.2006.08.024
Qian, Y., Tao, J., Li, X., Chen, H., Lu, Q., Yang, J., … Liu, X.
(2018). Peripheral inflammation/immune indicators of chemosensitivity
and prognosis in breast cancer patients treated with neoadjuvant
chemotherapy. Onco Targets Ther, 11 , 1423-1432.
doi:10.2147/OTT.S148496
Rapp, S. R., Gaussoin, S. A., Sachs, B. C., Chelune, G., Supiano, M. A.,
Lerner, A. J., … Group, S. R. (2020). Effects of intensive versus
standard blood pressure control on domain-specific cognitive function: a
substudy of the SPRINT randomised controlled trial. Lancet Neurol,
19 (11), 899-907. doi:10.1016/S1474-4422(20)30319-7
Schmittgen, T. D., & Livak, K. J. (2008). Analyzing real-time PCR data
by the comparative C(T) method. Nat Protoc, 3 (6), 1101-1108.
Shenoy, A., Dwork, A., Elkind, M. S. V., Marshall, R., Morgello, S., &
Gutierrez, J. (2018). Brain Large Artery Lymphocytic Inflammation and
Human Immunodeficiency Virus-Related Brain Arterial Remodeling. J
Virol, 92 (12)doi:10.1128/JVI.00081-18
Skelly, D. T., Griffin, E. W., Murray, C. L., Harney, S., O’Boyle, C.,
Hennessy, E., … Cunningham, C. (2018). Acute transient cognitive
dysfunction and acute brain injury induced by systemic inflammation
occur by dissociable IL-1-dependent mechanisms. Mol
Psychiatry doi:10.1038/s41380-018-0075-8
Stuhec, M., Keuschler, J., Serra-Mestres, J., & Isetta, M. (2017).
Effects of different antihypertensive medication groups on cognitive
function in older patients: A systematic review. Eur Psychiatry,
46 , 1-15. doi:10.1016/j.eurpsy.2017.07.015
Suzuki, K., Shinohara, M., Uno, Y., Tashiro, Y., Gheni, G., Yamamoto,
M., … Sato, N. (2021). Deletion of B-cell translocation gene 2
(BTG2) alters the responses of glial cells in white matter to chronic
cerebral hypoperfusion. J Neuroinflammation, 18 (1), 86.
doi:10.1186/s12974-021-02135-w
Tan, Y., Zhang, Y., He, J., Wu, F., Wu, D., Shi, N., … Chen, W.
(2022). Dual specificity phosphatase 1 attenuates inflammation-induced
cardiomyopathy by improving mitophagy and mitochondrial metabolism.Mol Metab, 64 , 101567. doi:10.1016/j.molmet.2022.101567
Verhaaren, B. F., Vernooij, M. W., de Boer, R., Hofman, A., Niessen, W.
J., van der Lugt, A., & Ikram, M. A. (2013). High blood pressure and
cerebral white matter lesion progression in the general population.Hypertension, 61 (6), 1354-1359.
doi:10.1161/HYPERTENSIONAHA.111.00430
Vinh, A., Chen, W., Blinder, Y., Weiss, D., Taylor, W. R., Goronzy, J.
J., … Guzik, T. J. (2010). Inhibition and genetic ablation of the
B7/CD28 T-cell costimulation axis prevents experimental hypertension.Circulation, 122 (24), 2529-2537.
doi:10.1161/CIRCULATIONAHA.109.930446
Wei, Z., Spizzo, I., Diep, H., Drummond, G. R., Widdop, R. E., & Vinh,
A. (2014). Differential phenotypes of tissue-infiltrating T cells during
angiotensin II-induced hypertension in mice. PLoS One, 9 (12),
e114895. doi:10.1371/journal.pone.0114895
Zenaro, E., Pietronigro, E., Della Bianca, V., Piacentino, G., Marongiu,
L., Budui, S., … Constantin, G. (2015). Neutrophils promote
Alzheimer’s disease-like pathology and cognitive decline via LFA-1
integrin. Nat Med, 21 (8), 880-886. doi:10.1038/nm.3913
Zhang, C. E., Wong, S. M., Uiterwijk, R., Backes, W. H., Jansen, J. F.
A., Jeukens, C., … Staals, J. (2019). Blood-brain barrier leakage
in relation to white matter hyperintensity volume and cognition in small
vessel disease and normal aging. Brain Imaging Behav, 13 (2),
389-395. doi:10.1007/s11682-018-9855-7