Figure 6
Angiotensin II infusion promotes transcriptomic changes in the
brain which is modulated by treatment with hydralazine. Volcano plot of
differentially expressed genes in the brains of mice infused withA: vehicle vs angiotensin II or B: angiotensin II vs
angiotensin II + hydralazine. The threshold of differential expression
is p-value <0.05. The horizontal axis is the log2 fold change
of genes. The vertical axis is statistical significance scaled as -log
10 p-value. Each dot represents an individual gene (blue: no significant
difference; red: upregulated expression; green: downregulated
expression). The top upregulated and downregulated genes in brains of
mice infused with C: vehicle vs angiotensin II or D:angiotensin II vs angiotensin II + hydralazine. Upregulated genes in red
and downregulated genes in blue. The colour scale represents the log10
(average FPKM + 1) value.