Figure 7
Angiotensin II infusion promotes transcriptomic changes in the hippocampus which is modulated by treatment with hydralazine. Volcano plot of differentially expressed genes in the hippocampus of mice infused with A: vehicle vs angiotensin II or B:angiotensin II vs angiotensin II + hydralazine. The threshold of differential expression is p-value <0.05. The horizontal axis is the log2 fold change of genes. The vertical axis is statistical significance scaled as -log 10 p-value. Each dot represents an individual gene (blue: no significant difference; red: upregulated expression; green: downregulated expression). The top upregulated and downregulated genes in hippocampus of mice infused with C:vehicle vs angiotensin II or D: angiotensin II vs angiotensin II + hydralazine. Upregulated genes in red and downregulated genes in blue. The colour scale represents the log10 (average FPKM + 1) value.