Figure 7
Angiotensin II infusion promotes transcriptomic changes in the
hippocampus which is modulated by treatment with hydralazine. Volcano
plot of differentially expressed genes in the hippocampus of mice
infused with A: vehicle vs angiotensin II or B:angiotensin II vs angiotensin II + hydralazine. The threshold of
differential expression is p-value <0.05. The horizontal axis
is the log2 fold change of genes. The vertical axis is statistical
significance scaled as -log 10 p-value. Each dot represents an
individual gene (blue: no significant difference; red: upregulated
expression; green: downregulated expression). The top upregulated and
downregulated genes in hippocampus of mice infused with C:vehicle vs angiotensin II or D: angiotensin II vs angiotensin
II + hydralazine. Upregulated genes in red and downregulated genes in
blue. The colour scale represents the log10 (average FPKM + 1) value.