Conclusion
With the technological advance of next-generation sequencing and
bioinformatic analysis, lncRNAs have been identified as potential
oncogenes or tumor suppressor genes that play important roles in
tumorigenesis. ZFAS1 , a newly discovered lncRNA, was highly
upregulated in glioma. The aberrant expression of lncRNAs ZFAS1in glioma contributes to a better understanding of the molecular
mechanisms and pathways in glioma as lncRNAs have now been demonstrated
to be a critical cellular regulatory network in a variety of cancers,
including glioma. In short, amplified ZFAS1 was found to be
significantly associated with a variety of clinicopathological features
and prognoses, including TNM stage, lymph node metastasis, and overall
survival. In vitro , ZFAS1 knockdown inhibited cell
proliferation, cell migration and invasion, and promoted cell apoptosis
in glioma, implying that ZFAS1 played a role in tumorigenesis and
progression. ZFAS1 molecular mechanisms implicated in
gliomagenesis, such as competing endogenous RNA (ceRNA) and sponging for
certain microRNAs, have been studied. These mechanisms can affectZFAS1 gene expression and the signalling protein in
gliomagenesis. Furthermore, ZFAS1 is involved in several
signalling pathways that lead to gliomagenesis, such as the EMT and
Notch signalling pathways. Each mechanism or pathway is not independent,
but rather interacts with others. Overall, a deep understanding ofZFAS1 mechanisms in glioma is crucial for better innovation,
targeted therapies, and translation of novel anticancer treatments to
precision medicine which may improve the clinical outcomes. Future
studies to produce further uncover the mechanism of ZFAS1 are
necessary to enhance the prognosis of glioma patients.