Conclusion
With the technological advance of next-generation sequencing and bioinformatic analysis, lncRNAs have been identified as potential oncogenes or tumor suppressor genes that play important roles in tumorigenesis. ZFAS1 , a newly discovered lncRNA, was highly upregulated in glioma. The aberrant expression of lncRNAs ZFAS1in glioma contributes to a better understanding of the molecular mechanisms and pathways in glioma as lncRNAs have now been demonstrated to be a critical cellular regulatory network in a variety of cancers, including glioma. In short, amplified ZFAS1 was found to be significantly associated with a variety of clinicopathological features and prognoses, including TNM stage, lymph node metastasis, and overall survival. In vitro , ZFAS1 knockdown inhibited cell proliferation, cell migration and invasion, and promoted cell apoptosis in glioma, implying that ZFAS1 played a role in tumorigenesis and progression. ZFAS1 molecular mechanisms implicated in gliomagenesis, such as competing endogenous RNA (ceRNA) and sponging for certain microRNAs, have been studied. These mechanisms can affectZFAS1 gene expression and the signalling protein in gliomagenesis. Furthermore, ZFAS1 is involved in several signalling pathways that lead to gliomagenesis, such as the EMT and Notch signalling pathways. Each mechanism or pathway is not independent, but rather interacts with others. Overall, a deep understanding ofZFAS1 mechanisms in glioma is crucial for better innovation, targeted therapies, and translation of novel anticancer treatments to precision medicine which may improve the clinical outcomes. Future studies to produce further uncover the mechanism of ZFAS1 are necessary to enhance the prognosis of glioma patients.