Discussion
Scoping review analysis revealed five original articles published
between 2017 and 2020, focusing on long non-coding RNA ZFAS1 and
their roles in glioma. ZFAS1 levels are higher in grade III and
IV glioblastoma than in lower grade glioma, such as type I and II.
Silencing or knocking down ZFAS1 in glioma cell lines, altered
various cellular processes including the cell cycle activity, invasion,
migration, and specific signalling pathways such as EMT, Notch
signalling pathway, as well as miRNA signalling as described in Table 1.
Table 1 summarises the analyses and results from the five selected
articles. This suggests the relevance of ZFAS1 as a potential
target for glioma.