1 |
none |
>99 |
90, 88e
(>99:1; >99:1) |
Different nickel catalysts instead of Ni(DME)Cl2
|
Different nickel catalysts instead of Ni(DME)Cl2
|
Different nickel catalysts instead of Ni(DME)Cl2
|
Different nickel catalysts instead of
Ni(DME)Cl2
|
2 |
Ni(DME)Br2
|
54 |
49 (>99:1;
>99:1) |
3 |
Ni(TMEDA)Cl2
|
>99 |
86 (99:1;
>99:1) |
4 |
Ni(acac)2
|
>99 |
83 (95:5;
>99:1) |
5 |
Ni(OAc)2·4H2O |
>99 |
84 (98:2; >99:1) |
6 |
NiCl2·6H2O |
>99 |
82
(96:4; >99:1) |
7 |
No Ni(DME)Cl2
|
0 |
N.D. |
Different bases instead of t-BuOK |
Different bases instead of
t-BuOK |
Different bases instead of t-BuOK |
Different
bases instead of t-BuOK |
8 |
EtOK |
>99 |
83 (95:5;
>99:1) |
9 |
KOH |
21 |
18 (90:10; >99:1) |
10 |
KF |
0 |
N.D. |
11 |
t-BuONa |
65 |
59 (>99:1;
>99:1) |
12 |
t-BuOLi |
5 |
2 (>99:1;
>99:1) |
13 |
No activator |
0 |
N.D. |
Different solvents instead of THF |
Different solvents instead of THF |
Different solvents instead of THF |
Different solvents instead of
THF |
14 |
CH3CN |
>99 |
88 (99:1;
>99:1) |
15 |
DME |
>99 |
90 (>99:1;
>99:1) |
16 |
CH2Cl2
|
0 |
N.D. |
Different temperatures instead of -30 ºC |
Different temperatures
instead of -30 ºC |
Different temperatures instead of -30 ºC |
Different
temperatures instead of -30 ºC |
17 |
under -40 ºC |
0 |
N.D. |
18 |
under 25 ºC |
84 |
49
(90:10; >99:1) |