Figure 1. Binding of S glycoprotein trimers to hACE2-Fc and
mvACE2-Fc receptors. (A) Representative binding profiles of S
glycoprotein trimers to the hACE2-Fc receptor. The hACE2-Fc receptor was
immobilized to biosensors, and binding to S glycoprotein trimers
(SD614G, SD614G+Y453F, and
SD614G+ Δ69-70+Y453F) was measured by bio-layer
interferometry. (B) Representative binding profiles of S
glycoprotein trimers to dimeric mvACE2-Fc receptors. The mvACE2-Fc
receptor was immobilized to biosensors and binding to S glycoprotein
trimers (SD614G, SD614G+Y453F, and
SD614G+ Δ69-70+Y453F) was measured by bio-layer
interferometry (C) Comparison of binding affinity (Kd) measured by
bio-layer interferometry of S glycoprotein trimers to hACE2-Fc or
mvACE2-Fc receptors.