Inclusion and exclusion criteria are as follows:
Inclusion criteria: (1) HCMV-infected group:HCMV-DNA ≥ 4.0 × 102 copies/ml in the urine of child, and the child has not received antiviral treatment; (2) Control group (no-HCMV-infected):HCMV-DNA < 4.0 × 102copies/ml in the urine of children and diagnosed as HCMV-infected.
Exclusion criteria: All subjects in this experiment should meet the following exclusion criteria: (1) active or known chronic infection (such as autoimmune disease, diabetes, and cardiovascular disease); (2) infectious diseases (hepatitis virus, herpes virus, rubella virus, rubella virus, mycoplasma, chlamydia, AIDS, syphilis, toxoplasma gondii, and other infections); (3) serious blood disease; (4) history of malignancy.