3.3.1 Sample characteristics and correlation analysis
The study included a total of 260 samples. The dose range of icariin and derivatives was 3-300mg/kg/day, and the treatment period was 0.25-90 days. The time-dose-efficacy distribution is shown in the figure (Figure 7). Meanwhile, Kendall analysis was used for correlation analysis of categorical variables (Figure 8A), and Pearson analysis was used for correlation analysis of continuous variables (Figure 8B). The analysis results show that the absolute value of the correlation between each feature is less than 0.35, suggesting that the risk of collinearity is low.