3.2.5 Apoptosis regulators
Icariin and its derivatives have also shown significant efficacy in the regulation of Apoptosis regulators (Table 4) . It significantly up-regulated BCL-2 (p = 0.000) while also exhibiting a potent inhibitory effect on caspase-1 (p = 0.000). Reassuringly, the meta-analysis of the efficacy of icariin on caspase-1 also demonstrated low heterogeneity (I2 = 7.9%, p = 0.297).