IL-1β
Icariin and its derivatives significantly reduced the level of IL-1β in
the 10 studies included [n = 204, SMD =-5.698, 95%CI (-7.307,
-4.089), p = 0.000] (Figure 5B ). Given the significant
heterogeneity observed across studies (I2 =
84.1%, p = 0.000), subgroup analysis was performed to explore
the sources of heterogeneity. In the subgroup analysis by species, the
heterogeneity of the ”mice” group was significantly improved. In
addition, the heterogeneity of the ”0-5 days” subgroup categorized by
treatment duration was also significantly improved. This suggests that
species and treatment duration are important sources of heterogeneity in
the meta-analysis of IL-1β (Table 3) .