4.1 Summary of the evidence
This investigation comprised the primary meta-analysis of icariin and its derivatives in the management of inflammation, accompanied by a machine learning analysis on the sample dataset. In total, 19 studies were incorporated, with 370 animals included in the meta-analysis and 260 animals analyzed through machine learning techniques. The results demonstrated that icariin and its derivatives possess the potential to treat many diseases by decreasing levels of cytokines via regulating related pathways.