2.1.4 Data extraction
Two researchers independently extracted the following information from
the literature: (1) The author’s name and publication year. (2) Details
of the animal model used in the study, including the type, gender, and
sample size. (3) The method used to induce inflammation in the model.
(4) The method used to induce anesthesia. (5) Details of the treatment
drugs used in the intervention group, including the name, dose and
timing of treatment. (6) Details of the treatment drugs used in the
model group, including the name, dose and timing of treatment. For
included drug doses, the highest dose was recorded. If the data were
presented in graphical form, the original author was contacted to obtain
the data. If the original data could not be obtained, digital ruler
software was used to measure the data from the image.
2.1.5 Risk of bias
assessment
To evaluate the quality of literature on the use of icariin for treating
inflammatory diseases, a risk of bias Assessment was conducted using the
SYRCLE list proposed by Hooijmans.et al (Hooijmans et al., 2014). The
assessment consisted of 10 items, including: (1) Sequence generation;
(2) Baseline characteristics; (3) Allocation concealment; (4) Random
housing; (5) Blinding of performance bias; (6) Random outcome
assessment; (7) Blinding detection bias; (8) Incomplete outcome data;
(9) Selective outcome reporting; (10) Other sources of bias. Each study
was given a total score of ten points, with each item worth one point.
The Risk of Bias Assessment was performed independently by two
researchers, and in case of any discrepancies, the results were reviewed
by a third researcher for arbitration.