(1) Subgroup analysis based on dose intervals |
(1)
Subgroup analysis based on dose intervals |
(1) Subgroup
analysis based on dose intervals |
(1) Subgroup analysis based
on dose intervals |
(1) Subgroup analysis based on dose
intervals |
0-10mg/kg/day |
n = 32 |
-3.393 (-5.130, -1.656) |
p =
0.000 |
I2 = 56.6% |
11-20mg/kg/day |
n = 36 |
-8.817 (-16.983, -0.650) |
p =
0.034 |
I2 = 93.8% |
30-50mg/kg/day |
n = 12 |
-6.745 (-9.910, -3.580) |
p =
0.000 |
- |
51-100mg/kg/day |
n = 78 |
-7.013 (-9.389, -4.636) |
p =
0.000 |
I2 = 70.8% |
above 100mg/kg/day |
n = 70 |
-6.159 (-11.487, -0.832) |
p
= 0.023 |
I2 = 93.4% |
(2) Subgroup analysis based on animal species |
(2)
Subgroup analysis based on animal species |
(2) Subgroup
analysis based on animal species |
(2) Subgroup analysis based
on animal species |
(2) Subgroup analysis based on animal
species |
Rats |
n = 88 |
-8.198 (-12.134, -4.262) |
p = 0.000 |
I2 = 88.9% |
Mice |
n = 150 |
-5.314 (-6.765, -3.864) |
p = 0.000 |
I2 = 74.2% |
(3) Subgroup analysis based on drug duration |
(3)
Subgroup analysis based on drug duration |
(3) Subgroup
analysis based on drug duration |
(3) Subgroup analysis based
on drug duration |
(3) Subgroup analysis based on drug
duration |
0-5 days |
n = 72 |
-6.471 (-7.806, -5.136) |
p = 0.000 |
I2 = 10.5% |
5-10 days |
n = 12 |
-2.524 (-4.107, -0.942) |
p = 0.002 |
- |
11-20 days |
n = 70 |
-6.159 (-11.487, -0.832) |
p = 0.023 |
I2 = 93.4% |
20-50days |
n = 14 |
-3.679 (-5.485, -1.872) |
p = 0.000 |
- |
above 50 days |
n = 70 |
-8.725 (-14.100, -3.350) |
p =
0.001 |
I2 = 91.4% |
(4) Subgroup analysis based on sex |
(4) Subgroup
analysis based on sex |
(4) Subgroup analysis based on sex |
(4) Subgroup analysis based on sex |
(4) Subgroup
analysis based on sex |
Male |
n = 198 |
-6.968 (-8.891, -5.044) |
p = 0.000 |
I2 = 85.1% |
Female |
n = 20 |
-5.171 (-11.265, 0.923) |
p = 0.096 |
I2 = 80.7% |
NA |
n = 20 |
-4.297 (-5.952, -2.642) |
p = 0.096 |
- |
(5) Subgroup analysis based on type of diseases |
(5)
Subgroup analysis based on type of diseases |
(5) Subgroup
analysis based on type of diseases |
(5) Subgroup analysis
based on type of diseases |
(5) Subgroup analysis based on type
of diseases |
Local inflammation |
n = 28 |
-9.152 (-11.846, -6.458) |
p
= 0.884 |
I2 = 0.0% |
Circulatory system |
n = 44 |
-8.271 (-17.515, -0.973) |
p
= 0.000 |
I2 = 95.4% |
Digestive system |
n = 28 |
-4.923 (-9.936, -0.091) |
p =
0.003 |
I2 = 88.6% |
Urinary system |
n = 40 |
-5.616 (-8.498, -2.733) |
p =
0.055 |
I2 = 72.9% |
Nervous system |
n = 40 |
-8.078 (-10.268, -5.889) |
p =
0.275 |
I2 = 16.2% |
Respiratory system |
n = 16 |
-4.777 (-6.800, -2.755) |
p
= 0.000 |
- |
Motion system |
n = 20 |
-3.571 (-4.560, -2.582) |
p =
0.000 |
- |