2.2.1 Research object and variable selection
The data source used in this study is the literature included in the
Meta-analysis, and its inclusion and exclusion criteria are the same as
those of the Meta-analysis. However, it is important to note that data
from different studies with different sample sizes may introduce
potential weighting factors leading to interfere with results in machine
learning. We collected samples for all doses and durations in each
literature. The relevant sample data of each document is interpolated
with the average value of the corresponding index of the document. The
sample data consisted of independent variables such as dose and
treatment time. The dependent variable is a continuous variable, and we
use TNF-α improvement rate ((Mean of control group-Mean of experimental
group)/Mean of control group) as an index to evaluate the effectiveness
of inflammation treatment.