5 Conclusion
Icariin and its derivatives have shown a significant improvement effect on inflammation-related diseases, and there is more favorable effect of inhibiting inflammation in respiratory, urinary, neurological and digestive diseases as well as when the dose is more than 27.52 mg/kg/day and course is more than 31.22 days. It has multiple therapeutic mechanisms including NF-κB pathway, P38 MAPK pathway, and PI3K/Akt pathway in different inflammatory diseases. Icariin and its derivatives may be a promising drug in the treatment of many diseases via inhibiting inflammation.