4.1 Summary of the evidence
This investigation comprised the primary meta-analysis of icariin and
its derivatives in the management of inflammation, accompanied by a
machine learning analysis on the sample dataset. In total, 19 studies
were incorporated, with 370 animals included in the meta-analysis and
260 animals analyzed through machine learning techniques. The results
demonstrated that icariin and its derivatives possess the potential to
treat many diseases by decreasing levels of cytokines via regulating
related pathways.