Study(year) Disease Species (sex, n = experimental
group for meta-analysis/model group, age, weight) Model (method) Treatment group
(drug, administration, dose, duration) Model group
(administration, duration) Outcome index
Wu et al. (2011) Inflammation C57BL mice (Female, 4/4, 8-10 weeks) LPS((1mg/kg) Gavage, ICT, 25/50/100mg/kg/d, 3 days Gavage, H2O, 3 days
Li et al. (2014) Inflammation BALB/c mice (Male, 10/10, 6 weeks) Cigarettes (15 mg nicotine and 195 mg tar, 3 month) Gavage, ICA,25/50/100mg/kg/d, 90 days No procedures ①⑤
Hu et al. (2016) Atherosclerosis (AS) Wistar rats (Male, 7/7, 180-220 g) High-cholesterol diet (HCD, 83.8 % normal diet, 3.5 % cholesterol, 10 % animal oil, 0.2 % propylthiouracil, 0.5 % sodium cholate, and 5 % refined sugar, 9 weeks) Gavage, ICA,30/60mg/kg/d, 28 days No mention ①③⑩⑪
Fu et al. (2018) Myocardial fibrosis Spontaneously hypertensive rats:SHRs(Male, 10/20, 13 weeks) Spontaneously hypertensive rats Gavage, ICS II, 4/8/16mg/kg/d, 84 days Gavage, distilled water, 84 days ①②③④⑤
Su et al. (2018) Lupus nephritis (LN) MRL/lpr mice (10/10, 10 weeks) MRL/lpr mice Gavage, ICA, 10mg/kg/d, 56 days Gavage, saline, 56 days ①②⑨⑬
Zhang et al. (2017) IgA nephropathy SD rats (Male, 15/15, 6 weeks, 180-200 g) 0.1% BGG (8 weeks) Gavage, ICA, 10mg/kg/d, 42 days Gavage, saline, 42 days ②④⑤⑧⑨⑬
Ma et al. (2015) Acute renal injury BALB/c mice (Male, 10/10, 20-22 g) Cisplatin (15 mg/kg) Gavage, ICA, 30/60mg/kg/d, 5 days Gavage, saline, 5 days ⑩⑪⑭
Guo et al. (2010) Brain dysfunction SD rats (Male, 14/14, 10-14 weeks, 250-300 g) LPS (10μl) Gavage, ICA, 30/60/120mg/kg/d, 17 days Gavage, distilled water, 17 days ①②
Xiong et al. (2016) Cerebral I/R SD rats (Male, 5/5, 16 weeks, 250-280 g) Reperfusion after MACO (24h) Gavage, ICA, 10/30mg/kg/d, 3 days Gavage, saline, 3 days ②④⑤⑥⑦
Deng et al. (2016) Cerebral I/R SD rats (Male, 5/5, 250-280 g) Reperfusion after MACO (24h) Gavage, ICS II, 10/30mg/kg/d, 3 days Gavage, saline, 3 days ②④⑤⑥⑦⑧
Li et al. (2018) SCI C57BL mice (Male, 6/6, 8 weeks) Spinal cord after laminectomy Gavage, ICA, 13.53/33.84mg/kg/d, 3 days Gavage, saline, 3 days ①②⑩⑪⑭⑮
Xu et al. (2010) Acute lung inflammatory C57BL mice (Male, 8/8, 11-12 weeks, 22-24 g) LPS (5 mg/ kg) Intraperitoneal injection, ICA, 20mg/kg/d, 0.25 days Intraperitoneal injection, PBS (Phosphate Buffered Saline), 0.25 days
Wei et al. (2015) Asthma BALB/c mice (Female, 20/20,12-16 g) 3% OVA ovalbumin (21 days) Gavage, ICA, 20/50/100mg/kg/d, 56 days Gavage, saline, 56 days ③④
Xie et al. (2018) Acute kidney injury C57BL mice (Male, 10/10, 38-44 weeks) cecal ligation and perforation (CLP) Intraperitoneal injection, ICA, 30/60mg/kg/d, 3 days No mention ①②③⑩⑪⑭⑮
Zhang et al. (2015) Intestinal I/R SD rats (Male, 8/8, 180-220 g) ischemiaereperfusion (I/R) Gavage, ICA, 30/60mg/kg/d, 3 days Gavage, 0.1% DMSO, 3 days ①③⑩⑭
Shao et al. (2015) Osteolysis C57BL mice (Male, 21/21, 7-8 weeks) 20 mg Ti particle Gavage, ICA,100/300mg/kg/d, 14 days Gavage, saline, 14 days ①②③
Tao et al. (2013) Colitis C57BL mice (Female, 6/6, 8 weeks, 19-20 weeks) 2.5% dextran sulfate sodium DSS (7 days) Gavage, ICA,3/10mg/kg/d, 10 days, Gavage, drinking water, 10 days ①⑫
Zhang et al. (2018) Periodontitis Mini pig (Female, 6/6) Alveolar bone defects Local injection, ICA,0.1 μg/mL, 84 days Local injection, saline, 84 days ②⑫
Zhou et al. (2011) Tumor BALB/c mice (Female, 5/5, 6-8 weeks) Tumor inoculation Intraperitoneal injection, ICA, 100mg/kg/d No mention