3.9 Baicalin
Baicalin, one of the flavonoid compounds, is the main active component
of traditional Chinese medicine Scutellaria baicalensis Georgi
(C. Li, Zhou, Lin, & Zuo, 2009). It has been shown that baicalin can
alleviate the development of atherosclerosis through its
anti-adipogenic, anti-inflammatory and antioxidant effects (Wu et al.,
2018). The expression of miR-126 was found to be reduced in the
peripheral blood of atherosclerotic
patients (Y. Jiang et al., 2014).
High mobility histone B1 (HMGB1) is an essential facilitator of
atherosclerosis by enhancing inflammation (Boteanu et al., 2017). It has
been found that baicalin induces the upregulation of miR-126-5p and the
downregulation of HMGB1, inhibiting ox-LDL-induced proliferation and
migration of VSMCs (Z. Chen et al., 2019).