3.5 Genkwanin
Genkwanin is one of the major non-glycosylated flavonoids extracted fromDaphne genkwa Siebold & Zucc. (Y. Bao et al., 2019). MKP-1 is a key negative regulator of macrophage signaling in response to inflammatory stimulis and is responsible for shutting down the production of pro-inflammatory cytokines (P. Chen et al., 2002; Chi et al., 2006). Genkwanin was proved to potently decrease the production of proinflammatory mediators through down-regulating miR-101 and increasing MKP-1 (Y. Gao et al., 2014).