3.14 Puerarin
Pueraria lobata is the dried roots of legumes Pueraria lobata(Willd.) Ohwi and Pueraria thunbergiana (Siebold & Zucc.)
Benth.. It is clinically used in the treatment of cardiovascular and
cerebrovascular diseases (S. Wang, Zhang, Wang, Gao, & Dai, 2020).
Puerarin, an active monomer in Pueraria lobata, was reported to inhibit
the proliferation and inflammation of VSMCs in atherosclerosis by
reducing the expression of miR-29b-3p, thereby increasing the expression
of insulin-like growth factor 1 (IGF1) (J. Li et al., 2023). Therefore,
puerarin may have a beneficial effect in the treatment of
atherosclerosis by regulating miRNA.