Abstract
Atherosclerosis is the leading
cause of numerous cardiovascular diseases with a high mortality rate.
Non-coding RNAs (ncRNAs), RNA molecules that do not encode proteins in
human genome transcripts, are known to play crucial roles in various
physiological and pathological processes. Recently, researches on the
regulation of atherosclerosis by ncRNAs, mainly including microRNAs,
long non-coding RNAs, and circular RNAs, have gradually become a hot
topic. Traditional Chinese
medicine has been proved to be effective in treating cardiovascular
diseases in China for a long time, and its active monomers have been
found to target a variety of atherosclerosis-related ncRNAs. These
active monomers of traditional Chinese medicine hold great potential as
drugs for the treatment of atherosclerosis.
Here,
we summarized current advancement of the molecular pathways by which
ncRNAs regulates atherosclerosis and mainly highlighted the mechanisms
of traditional Chinese medicine monomers in regulating atherosclerosis
through targeting ncRNAs.
Key words: non-coding RNAs; traditional Chinese medicine;
atherosclerosis; cardiovascular diseases; active monomer