References
Androulidaki, A., Wachsmuth, L., Polykratis, A., & Pasparakis, M. (2018). Differential role of MyD88 and TRIF signaling in myeloid cells in the pathogenesis of autoimmune diabetes. PLoS One, 13(3), e0194048. doi:10.1371/journal.pone.0194048
Aryal, B., & Suarez, Y. (2019). Non-coding RNA regulation of endothelial and macrophage functions during atherosclerosis. Vascular Pharmacology, 114, 64-75. doi:10.1016/j.vph.2018.03.001
Augoff, K., McCue, B., Plow, E. F., & Sossey-Alaoui, K. (2012). miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer. Molecular Cancer, 11, 5. doi:10.1186/1476-4598-11-5
Bai, Y., Wang, X., Zhao, S., Ma, C., Cui, J., & Zheng, Y. (2015). Sulforaphane protects against cardiovascular disease via Nrf2 activation. Oxidative Medicine and Cellular Longevity, 2015, 407580. doi:10.1155/2015/407580
Baker, A. H. (2011). MicroRNA 21 ”shapes” vascular smooth muscle behavior through regulating tropomyosin 1. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(9), 1941-1942. doi:10.1161/ATVBAHA.111.231985
Bao, M. H., Zhang, Y. W., & Zhou, H. H. (2013). Paeonol suppresses oxidized low-density lipoprotein induced endothelial cell apoptosis via activation of LOX-1/p38MAPK/NF-kappaB pathway. Journal of Ethnopharmacology, 146(2), 543-551. doi:10.1016/j.jep.2013.01.019
Bao, Y., Sun, Y. W., Ji, J., Gan, L., Zhang, C. F., Wang, C. Z., & Yuan, C. S. (2019). Genkwanin ameliorates adjuvant-induced arthritis in rats through inhibiting JAK/STAT and NF-kappaB signaling pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology, 63, 153036. doi:10.1016/j.phymed.2019.153036
Bazioti, V., La Rose, A. M., Maassen, S., Bianchi, F., de Boer, R., Halmos, B., … Westerterp, M. (2022). T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice. Nature communications, 13(1), 3799. doi:10.1038/s41467-022-31135-4
Bellosta, S., & Corsini, A. (2018). Statin drug interactions and related adverse reactions: an update. Expert Opinion on Drug Safety, 17(1), 25-37. doi:10.1080/14740338.2018.1394455
Boteanu, R. M., Suica, V. I., Uyy, E., Ivan, L., Dima, S. O., Popescu, I., … Antohe, F. (2017). Alarmins in chronic noncommunicable diseases: atherosclerosis, diabetes and cancer. Journal of Proteomics, 153, 21-29. doi:10.1016/j.jprot.2016.11.006
Bridges, M. C., Daulagala, A. C., & Kourtidis, A. (2021). LNCcation: lncRNA localization and function. The Journal of cell biology, 220(2)doi:10.1083/jcb.202009045
Chen, C., Cheng, G., Yang, X., Li, C., Shi, R., & Zhao, N. (2016). Tanshinol suppresses endothelial cells apoptosis in mice with atherosclerosis via lncRNA TUG1 up-regulating the expression of miR-26a. Am J Transl Res, 8(7), 2981-2991.
Chen, F. L., Yang, Z. H., Liu, Y., Li, L. X., Liang, W. C., Wang, X. C., … Hu, R. M. (2008). Berberine inhibits the expression of TNFalpha, MCP-1, and IL-6 in AcLDL-stimulated macrophages through PPARgamma pathway. Endocrine, 33(3), 331-337. doi:10.1007/s12020-008-9089-3
Chen, F. Y., Zhou, J., Guo, N., Ma, W. G., Huang, X., Wang, H., & Yuan, Z. Y. (2015). Curcumin retunes cholesterol transport homeostasis and inflammation response in M1 macrophage to prevent atherosclerosis. Biochemical and Biophysical Research Communications, 467(4), 872-878. doi:10.1016/j.bbrc.2015.10.051
Chen, L., Wang, C., Sun, H., Wang, J., Liang, Y., Wang, Y., & Wong, G. (2021). The bioinformatics toolbox for circRNA discovery and analysis. Briefings in Bioinformatics, 22(2), 1706-1728. doi:10.1093/bib/bbaa001
Chen, L., Yang, Z. S., Zhou, Y. Z., Deng, Y., Jiang, P., & Tan, S. L. (2020). Dihydromyricetin inhibits cell proliferation, migration, invasion and promotes apoptosis via regulating miR-21 in human cholangiocarcinoma cells. Journal of Cancer, 11(19), 5689-5699. doi:10.7150/jca.45970
Chen, L., Zhao, Z. W., Zeng, P. H., Zhou, Y. J., & Yin, W. J. (2022). Molecular mechanisms for ABCA1-mediated cholesterol efflux. Cell cycle (Georgetown, Tex.), 21(11), 1121-1139. doi:10.1080/15384101.2022.2042777
Chen, L. L. (2016). The biogenesis and emerging roles of circular RNAs. Nature reviews. Molecular cell biology, 17(4), 205-211. doi:10.1038/nrm.2015.32
Chen, P., Li, J., Barnes, J., Kokkonen, G. C., Lee, J. C., & Liu, Y. (2002). Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages. Journal of Immunology, 169(11), 6408-6416. doi:10.4049/jimmunol.169.11.6408
Chen, W., Li, X., Guo, S., Song, N., Wang, J., Jia, L., & Zhu, A. (2019). Tanshinone IIA harmonizes the crosstalk of autophagy and polarization in macrophages via miR-375/KLF4 pathway to attenuate atherosclerosis. International Immunopharmacology, 70, 486-497. doi:10.1016/j.intimp.2019.02.054
Chen, Y., Wang, S., Yang, S., Li, R., Yang, Y., Chen, Y., & Zhang, W. (2021). Inhibitory role of ginsenoside Rb2 in endothelial senescence and inflammation mediated by microRNA‑216a. Molecular Medicine Reports, 23(6)doi:10.3892/mmr.2021.12054
Chen, Z., Pan, X., Sheng, Z., Yan, G., Chen, L., & Ma, G. (2019). Baicalin suppresses the proliferation and migration of ox-LDL-VSMCs in atherosclerosis through upregulating miR-126-5p. Biological and Pharmaceutical Bulletin, 42(9), 1517-1523. doi:10.1248/bpb.b19-00196
Cheng, H. S., Sivachandran, N., Lau, A., Boudreau, E., Zhao, J. L., Baltimore, D., … Fish, J. E. (2013). MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways. EMBO Molecular Medicine, 5(7), 1017-1034. doi:10.1002/emmm.201202318
Cheng, S., Zhou, F., Xu, Y., Liu, X., Zhang, Y., Gu, M., … Jia, Y. (2019). Geniposide regulates the miR-101/MKP-1/p38 pathway and alleviates atherosclerosis inflammatory injury in ApoE(-/-) mice. Immunobiology, 224(2), 296-306. doi:10.1016/j.imbio.2018.12.005
Chi, H., Barry, S. P., Roth, R. J., Wu, J. J., Jones, E. A., Bennett, A. M., & Flavell, R. A. (2006). Dynamic regulation of pro- and anti-inflammatorycytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses. Proceedings of the National Academy of Sciences of the United States of America(7), 2274-2279. doi:10.1073/pnas.0510965103
Cyr, A. R., Huckaby, L. V., Shiva, S. S., & Zuckerbraun, B. S. (2020). Nitric Oxide and endothelial dysfunction. Critical Care Clinics, 36(2), 307-321. doi:10.1016/j.ccc.2019.12.009
Deng, Z., & Li, L. (2022). Effect of miR-663 on atherosclerosis by regulating the proliferation of vascular smooth muscle cells in lipid plaques. Vascular, 17085381221098826. doi:10.1177/17085381221098826
Di Mauro, V., Barandalla-Sobrados, M., & Catalucci, D. (2018). The noncoding-RNA landscape in cardiovascular health and disease. Non-coding RNA research, 3(1), 12-19. doi:10.1016/j.ncrna.2018.02.001
Eken, S. M., Jin, H., Chernogubova, E., Li, Y., Simon, N., Sun, C., … Maegdefessel, L. (2017). MicroRNA-210 enhances fibrous cap stability in advanced atherosclerotic lesions. Circulation Research, 120(4), 633-644. doi:10.1161/CIRCRESAHA.116.309318
Eren, E., Tufekci, K. U., Isci, K. B., Tastan, B., Genc, K., & Genc, S. (2018). Sulforaphane inhibits lipopolysaccharide-induced inflammation, cytotoxicity, oxidative stress, and miR-155 expression and switches to mox phenotype through activating extracellular signal-regulated kinase 1/2-nuclear factor erythroid 2-related factor 2/antioxidant response element pathway in murine microglial cells. Frontiers in Immunology, 9, 36. doi:10.3389/fimmu.2018.00036
Feinberg, M. W., & Moore, K. J. (2016). MicroRNA regulation of atherosclerosis. Circulation Research, 118(4), 703-720. doi:10.1161/CIRCRESAHA.115.306300
Fiedler, J., & Thum, T. (2016). New insights into miR-17-92 cluster regulation and angiogenesis. Circulation Research, 118(1), 9-11. doi:10.1161/CIRCRESAHA.115.307935
Fu, C., Yin, D., Nie, H., & Sun, D. (2018). Notoginsenoside R1 protects HUVEC against oxidized low density lipoprotein (ox-LDL)-Induced atherogenic response via down-regulating miR-132. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 51(4), 1739-1750. doi:10.1159/000495677
Fu, P. K., Wu, C. L., Tsai, T. H., & Hsieh, C. L. (2012). Anti-inflammatory and anticoagulative effects of paeonol on LPS-induced acute lung injury in rats. Evidence-based complementary and alternative medicine : eCAM, 2012, 837513. doi:10.1155/2012/837513
Fu, Y., Liu, B., Liu, J., Liu, Z., Liang, D., Li, F., … Yang, Z. (2012). Geniposide, from Gardenia jasminoides Ellis, inhibits the inflammatory response in the primary mouse macrophages and mouse models. International Immunopharmacology, 14(4), 792-798. doi:10.1016/j.intimp.2012.07.006
Gao, B., Huang, Q., Jie, Q., Zhang, H. Y., Wang, L., Guo, Y. S., … Luo, Z. J. (2015). Ginsenoside-Rb2 inhibits dexamethasone-induced apoptosis through promotion of GPR120 induction in bone marrow-derived mesenchymal stem cells. Stem Cells and Development, 24(6), 781-790. doi:10.1089/scd.2014.0367
Gao, F., Wang, X. C., Luo, Z. D., Hu, G. Q., Ma, M. Q., Liang, Y., … Lin, X. H. (2022). LncRNA HOXA11-AS promotes vascular endothelial cell injury in atherosclerosis by regulating the miR-515-5p/ROCK1 axis. ESC heart failure, 9(4), 2259-2271. doi:10.1002/ehf2.13815
Gao, J. H., Zeng, M. Y., Yu, X. H., Zeng, G. F., He, L. H., Zheng, X. L., … Tang, C. K. (2018). Visceral adipose tissue-derived serine protease inhibitor accelerates cholesterol efflux by up-regulating ABCA1 expression via the NF-kappaB/miR-33a pathway in THP-1 macropahge-derived foam cells. Biochemical and Biophysical Research Communications, 500(2), 318-324. doi:10.1016/j.bbrc.2018.04.066
Gao, Y., Liu, F., Fang, L., Cai, R., Zong, C., & Qi, Y. (2014). Genkwanin inhibits proinflammatory mediators mainly through the regulation of miR-101/MKP-1/MAPK pathway in LPS-activated macrophages. PLoS One, 9(5), e96741. doi:10.1371/journal.pone.0096741
Gong, L., Chang, H., Zhang, J., Guo, G., Shi, J., & Xu, H. (2018). Astragaloside IV protects rat cardiomyocytes from hypoxia-induced injury by down-regulation of miR-23a and miR-92a. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 49(6), 2240-2253. doi:10.1159/000493827
Guan, S., Shen, Y., Ge, H., Xiong, W., He, L., Liu, L., … Gao, Y. (2019). Dihydromyricetin alleviates diabetic neuropathic pain and depression comorbidity symptoms by inhibiting P2X(7) receptor. Frontiers in psychiatry, 10, 770. doi:10.3389/fpsyt.2019.00770
Guerrero-Beltran, C. E., Calderon-Oliver, M., Pedraza-Chaverri, J., & Chirino, Y. I. (2012). Protective effect of sulforaphane against oxidative stress: recent advances. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 64(5), 503-508. doi:10.1016/j.etp.2010.11.005
Gunning, P. W., Hardeman, E. C., Lappalainen, P., & Mulvihill, D. P. (2015). Tropomyosin - master regulator of actin filament function in the cytoskeleton. Journal of Cell Science, 128(16), 2965-2974. doi:10.1242/jcs.172502
Guo, F. X., Wu, Q., Li, P., Zheng, L., Ye, S., Dai, X. Y., … Wang, Q. (2019). The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling. Cell Death and Differentiation, 26(9), 1670-1687. doi:10.1038/s41418-018-0235-z
Guo, Y., Li, P., Gao, L., Zhang, J., Yang, Z., Bledsoe, G., … Chao, J. (2017). Kallistatin reduces vascular senescence and aging by regulating microRNA-34a-SIRT1 pathway. Aging Cell, 16(4), 837-846. doi:10.1111/acel.12615
Guttman, M., & Rinn, J. L. (2012). Modular regulatory principles of large non-coding RNAs. Nature, 482(7385), 339-346. doi:10.1038/nature10887
Hasan, S. T., Zingg, J. M., Kwan, P., Noble, T., Smith, D., & Meydani, M. (2014). Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice. Atherosclerosis, 232(1), 40-51. doi:10.1016/j.atherosclerosis.2013.10.016
Houghton, C. A., Fassett, R. G., & Coombes, J. S. (2016). Sulforaphane and other nutrigenomic Nrf2 activators: Can the clinician’s expectation be matched by the reality? Oxidative Medicine and Cellular Longevity, 2016, 7857186. doi:10.1155/2016/7857186
Huang, H. S., Huang, X. Y., Yu, H. Z., Xue, Y., & Zhu, P. L. (2020). Circular RNA circ-RELL1 regulates inflammatory response by miR-6873-3p/MyD88/NF-kappaB axis in endothelial cells. Biochemical and Biophysical Research Communications, 525(2), 512-519. doi:10.1016/j.bbrc.2020.02.109
Huang, Q., Gao, B., Jie, Q., Wei, B. Y., Fan, J., Zhang, H. Y., … Liu, J. (2014). Ginsenoside-Rb2 displays anti-osteoporosis effects through reducing oxidative damage and bone-resorbing cytokines during osteogenesis. Bone, 66, 306-314. doi:10.1016/j.bone.2014.06.010
Huang, Q., Wang, T., & Wang, H. Y. (2017). Ginsenoside Rb2 enhances the anti-inflammatory effect of omega-3 fatty acid in LPS-stimulated RAW264.7 macrophages by upregulating GPR120 expression. Acta Pharmacologica Sinica, 38(2), 192-200. doi:10.1038/aps.2016.135
Jia, S., Ma, W. D., Zhang, C. Y., Zhang, Y., Yao, Z. H., Quan, X. H., … Wang, C. X. (2019). Tanshinone IIA attenuates high glucose induced human VSMC proliferation and migration through miR-21-5p-mediated tropomyosin 1 downregulation. Archives of Biochemistry and Biophysics, 677, 108154. doi:10.1016/j.abb.2019.108154
Jiang, J., Mo, Z. C., Yin, K., Zhao, G. J., Lv, Y. C., Ouyang, X. P., … Tang, C. K. (2012). Epigallocatechin-3-gallate prevents TNF-alpha-induced NF-kappaB activation thereby upregulating ABCA1 via the Nrf2/Keap1 pathway in macrophage foam cells. International Journal of Molecular Medicine, 29(5), 946-956. doi:10.3892/ijmm.2012.924
Jiang, Y., Wang, H. Y., Li, Y., Guo, S. H., Zhang, L., & Cai, J. H. (2014). Peripheral blood miRNAs as a biomarker for chronic cardiovascular diseases. Scientific Reports, 4, 5026. doi:10.1038/srep05026
Lai, X. H., Lei, Y., Yang, J., & Xiu, C. K. (2018). Effect of microRNA-34a/SIRT1/p53 signal pathway on notoginsenoside R1 delaying vascular endothelial cell senescence. Chinese Journal of Chinese Metera Medica, 43(3), 577-584. doi:10.3969/j.issn.1000-4718.2018.12.002
Lei, W., Yan, Y., Ma, Y., Jiang, M., Zhang, B., Zhang, H., & Li, Y. (2022). Notoginsenoside R1 regulates ischemic myocardial lipid metabolism by activating the AKT/mTOR signaling pathway. Frontiers in Pharmacology, 13, 905092. doi:10.3389/fphar.2022.905092
Li, C., Yang, L., Wu, H., & Dai, M. (2018). Paeonol inhibits oxidized low-density lipoprotein-induced vascular endothelial cells autophagy by upregulating the expression of miRNA-30a. Frontiers in Pharmacology, 9, 95. doi:10.3389/fphar.2018.00095
Li, C., Zhou, L., Lin, G., & Zuo, Z. (2009). Contents of major bioactive flavones in proprietary traditional Chinese medicine products and reference herb of radix scutellariae. Journal of Pharmaceutical and Biomedical Analysis, 50(3), 298-306. doi:10.1016/j.jpba.2009.04.028
Li, F. P., Lin, D. Q., & Gao, L. Y. (2018). LncRNA TUG1 promotes proliferation of vascular smooth muscle cell and atherosclerosis through regulating miRNA-21/PTEN axis. European Review for Medical and Pharmacological Sciences, 22(21), 7439-7447. doi:10.26355/eurrev_201811_16284
Li, J., Li, Y., Yuan, X., Yao, D., Gao, Z., Niu, Z., … Zhang, Y. (2023). The effective constituent puerarin, from Pueraria lobata, inhibits the proliferation and inflammation of vascular smooth muscle in atherosclerosis through the miR-29b-3p/IGF1 pathway. Pharmaceutical Biology, 61(1), 1-11. doi:10.1080/13880209.2022.2099430
Li, R., Hu, Y., & Hou, S. (2022). An exploration of oral-gut pathogens mediating immune escape of pancreatic cancer via miR-21/PTEN axis. Frontiers in Microbiology, 13, 928846. doi:10.3389/fmicb.2022.928846
Li, S., Stockl, S., Lukas, C., Herrmann, M., Brochhausen, C., Konig, M. A., … Grassel, S. (2021). Curcumin-primed human BMSC-derived extracellular vesicles reverse IL-1beta-induced catabolic responses of OA chondrocytes by upregulating miR-126-3p. Stem Cell Research & Therapy, 12(1), 252. doi:10.1186/s13287-021-02317-6
Li, T., Pang, Q., Liu, Y., Bai, M., Peng, Y., & Zhang, Z. (2021). Sulforaphane protects human umbilical vein endothelial cells from oxidative stress via the miR-34a/SIRT1 axis by upregulating nuclear factor erythroid-2-related factor 2. Experimental and Therapeutic Medicine, 21(3), 186. doi:10.3892/etm.2021.9617
Li, X. Q., & Huang, T. Y. (2021). Notoginsenoside R1 alleviates high glucose-induced inflammation and oxidative stress in HUVECs via upregulating miR-147a. The Kaohsiung journal of medical sciences, 37(12), 1101-1112. doi:10.1002/kjm2.12433
Li, Y., Zhang, Y., Lu, J., Yin, Y., Xie, J., & Xu, B. (2021). Anti-inflammatory mechanisms and research progress of colchicine in atherosclerotic therapy. Journal of Cellular and Molecular Medicine, 25(17), 8087-8094. doi:10.1111/jcmm.16798
Li, Z., Xie, X., Fan, X., & Li, X. (2020). Long Non-coding RNA MINCR regulates miR-876-5p/GSPT1 axis to aggravate glioma progression. Neurochemical Research, 45(7), 1690-1699. doi:10.1007/s11064-020-03029-8
Liang, G., Wang, S., Shao, J., Jin, Y. J., Xu, L., Yan, Y., … Offermanns, S. (2022). Tenascin-X mediates flow-induced suppression of EndMT and atherosclerosis. Circulation Research, 130(11), 1647-1659. doi:10.1161/CIRCRESAHA.121.320694
Liao, X., Sharma, N., Kapadia, F., Zhou, G., Lu, Y., Hong, H., … Jain, M. K. (2011). Kruppel-like factor 4 regulates macrophage polarization. The Journal of clinical investigation, 121(7), 2736-2749. doi:10.1172/JCI45444
Libby, P. (2021). The changing landscape of atherosclerosis. Nature, 592(7855), 524-533. doi:10.1038/s41586-021-03392-8
Libby, P., Buring, J. E., Badimon, L., Hansson, G. K., Deanfield, J., Bittencourt, M. S., … Lewis, E. F. (2019). Atherosclerosis. Nature reviews. Disease primers, 5(1), 56. doi:10.1038/s41572-019-0106-z
Liu, Y., Li, C., Wu, H., Xie, X., Sun, Y., & Dai, M. (2018). Paeonol attenuated inflammatory response of endothelial cells via stimulating monocytes-derived exosomal MicroRNA-223. Frontiers in Pharmacology, 9, 1105. doi:10.3389/fphar.2018.01105
Liu, Y. R., Chen, J. J., & Dai, M. (2014). Paeonol protects rat vascular endothelial cells from ox-LDL-induced injury in vitro via downregulating microRNA-21 expression and TNF-alpha release. Acta Pharmacologica Sinica, 35(4), 483-488. doi:10.1038/aps.2013.190
Lu, T. X., & Rothenberg, M. E. (2018). MicroRNA. The Journal of allergy and clinical immunology, 141(4), 1202-1207. doi:10.1016/j.jaci.2017.08.034
Luo, H., Chen, J., Su, C., & Zha, L. (2022). Advances in the bioactivities of phytochemical saponins in the prevention and treatment of atherosclerosis. Nutrients, 14(23)doi:10.3390/nu14234998
M, Y., M, F., & CJ, L. (2008). miR-34a repression of SIRT1 regulates apoptosis. Proceedings of the National Academy of Sciences of the United States of America(36), 13421-13426. doi:10.1073/pnas.0801613105
Maitrias, P., Metzinger-Le Meuth, V., Nader, J., Reix, T., Caus, T., & Metzinger, L. (2017). The Involvement of miRNA in Carotid-Related Stroke. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(9), 1608-1617. doi:10.1161/ATVBAHA.117.309233
Meiler, S., Baumer, Y., Toulmin, E., Seng, K., & Boisvert, W. A. (2015). MicroRNA 302a is a novel modulator of cholesterol homeostasis and atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(2), 323-331. doi:10.1161/ATVBAHA.114.304878
Menghini, R., Casagrande, V., Cardellini, M., Martelli, E., Terrinoni, A., Amati, F., … Federici, M. (2009). MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation, 120(15), 1524-1532. doi:10.1161/CIRCULATIONAHA.109.864629
Okuyama, H., Langsjoen, P. H., Hamazaki3, T., Ogushi, Y., Hama, R., Kobayashi, T., & Uchino, H. (2015). Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms. Expert Review of Clinical Pharmacology(2), 189-199. doi:10.1586/17512433.2015.1011125
Ouyang, S., Zhang, O., Xiang, H., Yao, Y. H., & Fang, Z. Y. (2022). Curcumin improves atherosclerosis by inhibiting the epigenetic repression of lncRNA MIAT to miR-124. Vascular, 17085381211040974. doi:10.1177/17085381211040974
Pankratz, F., Hohnloser, C., Bemtgen, X., Jaenich, C., Kreuzaler, S., Hoefer, I., … Grundmann, S. (2018). MicroRNA-100 suppresses chronic vascular inflammation by stimulation of endothelial autophagy. Circulation Research, 122(3), 417-432. doi:10.1161/CIRCRESAHA.117.311428
Park, K. H., Park, Y. D., Han, J. M., Im, K. R., Lee, B. W., Jeong, I. Y., … Lee, W. S. (2006). Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from cudrania tricuspidata. Bioorganic & Medicinal Chemistry Letters, 16(21), 5580-5583. doi:10.1016/j.bmcl.2006.08.032
Perez-Sanchez, C., Aguirre, M. A., Ruiz-Limon, P., Abalos-Aguilera, M. C., Jimenez-Gomez, Y., Arias-de la Rosa, I., … Lopez-Pedrera, C. (2017). Ubiquinol effects on antiphospholipid syndrome prothrombotic profile: a randomized, placebo-controlled trial. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(10), 1923-1932. doi:10.1161/ATVBAHA.117.309225
Pope, A. J., Karrupiah, K., Kearns, P. N., Xia, Y., & Cardounel, A. J. (2009). Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production. The Journal of biological chemistry, 284(51), 35338-35347. doi:10.1074/jbc.M109.037036
Qian, W., Cai, X., Qian, Q., Zhuang, Q., Yang, W., Zhang, X., & Zhao, L. (2019). Astragaloside IV protects endothelial progenitor cells from the damage of ox-LDL via the LOX-1/NLRP3 inflammasome pathway. Drug Design, Development and Therapy, 13, 2579-2589. doi:10.2147/DDDT.S207774
Qin, H. W., Li, Y. J., Zhang, Z. X., Ren, K., Li, S. J., & Lu, Y. B. (2018). Anti-atherosclerosis effect of astragaloside is related to miR-33a /ABCA1 signaling. Chinese Journal of Pathophysiology, 34, 2120-2126.
Qin, H. W., Zhang, Q. S., Li, Y. J., Li, W. T., & Wang, Y. (2022). Molecular mechanism of astragaloside Ⅳ against atherosclerosis by regulating miR-17-5p and PCSK9/VLDLR signal pathway. Chinese Journal of Chinese Metera Medica, 47(2), 492-498. doi:10.19540/j.cnki.cjcmm.20210918.701
Qin, Y., Zheng, B., Yang, G. S., Zhou, J., Yang, H. J., Nie, Z. Y., … Wen, J. K. (2020). Tanshinone ⅡA inhibits VSMC inflammation and proliferation in vivo and in vitro by downregulating miR-712-5p expression. European Journal of Pharmacology, 880, 173140. doi:10.1016/j.ejphar.2020.173140
Ren, P., Wang, J., Li, L., Lin, X., Wu, G., Chen, J., … Zhang, H. (2021). Identification of key genes involved in the recurrence of glioblastoma multiforme using weighted gene co-expression network analysis and differential expression analysis. Bioengineered, 12(1), 3188-3200. doi:10.1080/21655979.2021.1943986
Ruparelia, N., & Choudhury, R. (2020). Inflammation and atherosclerosis: what is on the horizon? Heart (British Cardiac Society), 106(1), 80-85. doi:10.1136/heartjnl-2018-314230
Salmena, L., Poliseno, L., Tay, Y., Kats, L., & Pandolfi, P. P. (2011). A ceRNA hypothesis: the rosetta stone of a hidden RNA language? Cell, 146(3), 353-358. doi:10.1016/j.cell.2011.07.014
Shanahan, C. M., Cary, N. R., Metcalfe, J. C., & Weissberg, P. L. (1994). High expression of genes for calcification-regulating proteins in human atherosclerotic plaques. The Journal of clinical investigation, 93(6), 2393-2402. doi:10.1172/JCI117246
Shao, X., Liu, Z., Liu, S., Lin, N., & Deng, Y. (2021). Astragaloside IV alleviates atherosclerosis through targeting circ_0000231/miR-135a-5p/CLIC4 axis in AS cell model in vitro. Molecular and Cellular Biochemistry, 476(4), 1783-1795. doi:10.1007/s11010-020-04035-8
Sheedy, F. J. (2015). Turning 21: induction of miR-21 as a key switch in the inflammatory response. Frontiers in Immunology, 6, 19. doi:10.3389/fimmu.2015.00019
Shen, J., Wei, W., Wang, X., Yang, J., Lu, L., Lv, X., & Xue, X. (2020). Proliferation of vascular smooth muscle cells under ox-LDL Is regulated by alismatis rhizoma decoction via InhibitingERK1/2 and miR-17 approximately 92a cluster activation. Evidence-based complementary and alternative medicine : eCAM, 2020, 7275246. doi:10.1155/2020/7275246
Shen, L., Hu, Y., Lou, J., Yin, S., Wang, W., Wang, Y., … Wu, W. (2019). CircRNA‑0044073 is upregulated in atherosclerosis and increases the proliferation and invasion of cells by targeting miR‑107. Molecular Medicine Reports, 19(5), 3923-3932. doi:10.3892/mmr.2019.10011
Shi, X., Xie, X., Sun, Y., He, H., Huang, H., Liu, Y., … Dai, M. (2020). Paeonol inhibits NLRP3 mediated inflammation in rat endothelial cells by elevating hyperlipidemic rats plasma exosomal miRNA-223. European Journal of Pharmacology, 885, 173473. doi:10.1016/j.ejphar.2020.173473
Shou, X., Wang, Y., Jiang, Q., Chen, J., & Liu, Q. (2023). miR-126 promotes M1 to M2 macrophage phenotype switching via VEGFA and KLF4. PeerJ, 11, e15180. doi:10.7717/peerj.15180
Silva, J., Yu, X., Moradian, R., Folk, C., Spatz, M. H., Kim, P., … Liang, J. (2020). Dihydromyricetin protects the liver via changes in lipid metabolism and enhanced ethanol metabolism. Alcoholism, Clinical and Experimental Research, 44(5), 1046-1060. doi:10.1111/acer.14326
Simion, V., Zhou, H., Haemmig, S., Pierce, J. B., Mendes, S., Tesmenitsky, Y., … Feinberg, M. W. (2020). A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus. Nature communications, 11(1), 6135. doi:10.1038/s41467-020-19664-2
Son, D. J., Kumar, S., Takabe, W., Kim, C. W., Ni, C. W., Alberts-Grill, N., … Jo, H. (2013). The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis. Nature communications, 4, 3000. doi:10.1038/ncomms4000
Song, W., Pu, J., & He, B. (2014). Tanshinol protects human umbilical vein endothelial cells against hydrogen peroxide‑induced apoptosis. Molecular Medicine Reports, 10(5), 2764-2770. doi:10.3892/mmr.2014.2541
Song, Z., Wei, D., Chen, Y., Chen, L., Bian, Y., Shen, Y., … Pan, Y. (2019). Association of astragaloside IV-inhibited autophagy and mineralization in vascular smooth muscle cells with lncRNA H19 and DUSP5-mediated ERK signaling. Toxicology and Applied Pharmacology, 364, 45-54. doi:10.1016/j.taap.2018.12.002
Sun, D., Xiang, G., Wang, J., Li, Y., Mei, S., Ding, H., & Yan, J. (2020). miRNA 146b-5p protects against atherosclerosis by inhibiting vascular smooth muscle cell proliferation and migration. Epigenomics, 12(24), 2189-2204. doi:10.2217/epi-2020-0155
Sun, G., Li, Y., & Ji, Z. (2019). Up-regulation of MIAT aggravates the atherosclerotic damage in atherosclerosis mice through the activation of PI3K/Akt signaling pathway. Drug delivery, 26(1), 641-649. doi:10.1080/10717544.2019.1628116
Sun, Y., Liu, S., Yang, S., Chen, C., Yang, Y., Lin, M., … Chen, N. (2021). Mechanism of dihydromyricetin on inflammatory diseases. Frontiers in Pharmacology, 12, 794563. doi:10.3389/fphar.2021.794563
Tan, C., Zhou, L., Wen, W., & Xiao, N. (2021). Curcumin promotes cholesterol efflux by regulating ABCA1 expression through miR-125a-5p/SIRT6 axis in THP-1 macrophage to prevent atherosclerosis. The Journal of toxicological sciences, 46(5), 209-222. doi:10.2131/jts.46.209
Tan, L., Meng, L., Shi, X., & Yu, B. (2017). Knockdown of microRNA-17-5p ameliorates atherosclerotic lesions in ApoE(-/-) mice and restores the expression of very low density lipoprotein receptor. Biotechnology Letters, 39(7), 967-976. doi:10.1007/s10529-017-2337-y
Tan, Y. Q., Chen, H. W., & Li, J. (2020). Astragaloside IV: an effective drug for the treatment of cardiovascular diseases. Drug Design, Development and Therapy, 14, 3731-3746. doi:10.2147/DDDT.S272355
Tang, Y. L., Jiang, J. H., Wang, S., Liu, Z., Tang, X. Q., Peng, J., … Gu, H. F. (2015). TLR4/NF-kappaB signaling contributes to chronic unpredictable mild stress-induced atherosclerosis in ApoE-/- mice. PLoS One, 10(4), e0123685. doi:10.1371/journal.pone.0123685
Tao, H., Cao, W., Yang, J. J., Shi, K. H., Zhou, X., Liu, L. P., & Li, J. (2016). Long noncoding RNA H19 controls DUSP5/ERK1/2 axis in cardiac fibroblast proliferation and fibrosis. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, 25(5), 381-389. doi:10.1016/j.carpath.2016.05.005
Thum, T., & Mayr, M. (2012). Review focus on the role of microRNA in cardiovascular biology and disease. Cardiovascular Research, 93(4), 543-544. doi:10.1093/cvr/cvs085
Tousoulis, D., Kampoli, A. M., Tentolouris, C., Papageorgiou, N., & Stefanadis, C. (2012). The role of nitric oxide on endothelial function. Current Vascular Pharmacology, 10(1), 4-18. doi:10.2174/157016112798829760
Vanduchova, A., Anzenbacher, P., & Anzenbacherova, E. (2019). Isothiocyanate from Broccoli, Sulforaphane, and its properties. Journal of Medicinal Food, 22(2), 121-126. doi:10.1089/jmf.2018.0024
Wang, D., Lu, C., Sun, F., Cui, M., Mu, H., Duan, J., & Geng, H. (2017). A tanshinone I derivative enhances the activities of antibiotics against Staphylococcus aureus in vitro and in vivo. Research in Microbiology, 168(1), 46-54. doi:10.1016/j.resmic.2016.08.002
Wang, J. C., & Bennett, M. (2012). Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence. Circulation Research, 111(2), 245-259. doi:10.1161/CIRCRESAHA.111.261388
Wang, L., Shen, C., Wang, Y., Zou, T., Zhu, H., Lu, X., … Gu, D. (2019). Identification of circular RNA Hsa_circ_0001879 and Hsa_circ_0004104 as novel biomarkers for coronary artery disease. Atherosclerosis, 286, 88-96. doi:10.1016/j.atherosclerosis.2019.05.006
Wang, S., Zhang, S., Wang, S., Gao, P., & Dai, L. (2020). A comprehensive review on pueraria: Insights on its chemistry and medicinal value. Biomedicine and Pharmacotherapy, 131, 110734. doi:10.1016/j.biopha.2020.110734
Wang, W., Ma, F., & Zhang, H. (2020). MicroRNA-374 is a potential diagnostic biomarker for atherosclerosis and regulates the proliferation and migration of vascular smooth muscle cells. Cardiovascular diagnosis and therapy, 10(4), 687-694. doi:10.21037/cdt-20-444
Wang, Z., Shi, D., Zhang, N., Yuan, T., & Tao, H. (2021). MiR-217 promotes endothelial cell senescence through the SIRT1/p53 signaling pathway. Journal of Molecular Histology, 52(2), 257-267. doi:10.1007/s10735-020-09945-x
Wang, Z., Zhang, M., Wang, Z., Guo, Z., Wang, Z., & Chen, Q. (2020). Cyanidin-3-O-glucoside attenuates endothelial cell dysfunction by modulating miR-204-5p/SIRT1-mediated inflammation and apoptosis. BioFactors (Oxford, England), 46(5), 803-812. doi:10.1002/biof.1660
Wijesekara, N., Zhang, L. H., Kang, M. H., Abraham, T., Bhattacharjee, A., Warnock, G. L., … Hayden, M. R. (2012). miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets. Diabetes, 61(3), 653-658. doi:10.2337/db11-0944
Winter, J., Jung, S., Keller, S., Gregory, R. I., & Diederichs, S. (2009). Many roads to maturity: microRNA biogenesis pathways and their regulation. Nature Cell Biology, 11(3), 228-234. doi:10.1038/ncb0309-228
Wu, Y., Wang, F., Fan, L., Zhang, W., Wang, T., Du, Y., & Bai, X. (2018). Baicalin alleviates atherosclerosis by relieving oxidative stress and inflammatory responses via inactivating the NF-kappaB and p38 MAPK signaling pathways. Biomedicine and Pharmacotherapy, 97, 1673-1679. doi:10.1016/j.biopha.2017.12.024
Xiao, X., Xu, M., Yu, H., Wang, L., Li, X., Rak, J., … Zhao, R. C. (2021). Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src. Signal transduction and targeted therapy, 6(1), 354. doi:10.1038/s41392-021-00765-3
Xue, X., Deng, Y., Wang, J., Zhou, M., Liao, L., Wang, C., … Li, Y. (2021). Hydroxysafflor yellow A, a natural compound from Carthamus tinctorius L with good effect of alleviating atherosclerosis. Phytomedicine : international journal of phytotherapy and phytopharmacology, 91, 153694. doi:10.1016/j.phymed.2021.153694
Yang, D., Tan, S., Yang, Z., Jiang, P., Qin, C., Yuan, Q., … Chen, L. (2018). Dihydromyricetin attenuates TNF-alpha-Induced endothelial dysfunction through miR-21-mediated DDAH1/ADMA/NO signal pathway. BioMed research international, 2018, 1047810. doi:10.1155/2018/1047810
Yang, D., Yang, Z., Chen, L., Kuang, D., Zou, Y., Li, J., … Tan, S. (2020). Dihydromyricetin increases endothelial nitric oxide production and inhibits atherosclerosis through microRNA-21 in apolipoprotein E-deficient mice. Journal of Cellular and Molecular Medicine, 24(10), 5911-5925. doi:10.1111/jcmm.15278
Yang, H. X., Gao, Y., Jiang, H. B., & Liu, L. S. (2016). EGCG upregulated ABCA1 expression by decreasing miR-33 a generation to reduce lipid accumulation of macrophage-derived foam cells. Chinese Pharmacological Bulletin, 1279-1283, 1284. doi:10.3969 /j.issn.1001-1978.2016.09.018
Yin, J., Hou, X., & Yang, S. (2019). microRNA-338-3p promotes ox-LDL-induced endothelial cell injury through targeting BAMBI and activating TGF-beta/Smad pathway. Journal of Cellular Physiology, 234(7), 11577-11586. doi:10.1002/jcp.27814
Yin, R., Zhu, X., Wang, J., Yang, S., Ma, A., Xiao, Q., … Pan, X. (2019). MicroRNA-155 promotes the ox-LDL-induced activation of NLRP3 inflammasomes via the ERK1/2 pathway in THP-1 macrophages and aggravates atherosclerosis in ApoE-/- mice. Annals of palliative medicine, 8(5), 676-689. doi:10.21037/apm.2019.10.11
Yu, X. H., Deng, W. Y., Chen, J. J., Xu, X. D., Liu, X. X., Chen, L., … Ren, K. (2020). LncRNA kcnq1ot1 promotes lipid accumulation and accelerates atherosclerosis via functioning as a ceRNA through the miR-452-3p/HDAC3/ABCA1 axis. Cell Death & Disease, 11(12), 1043. doi:10.1038/s41419-020-03263-6
Yu, Y., Yan, R., Chen, X., Sun, T., & Yan, J. (2020). Paeonol suppresses the effect of ox-LDL on mice vascular endothelial cells by regulating miR-338-3p/TET2 axis in atherosclerosis. Molecular and Cellular Biochemistry, 475(1-2), 127-135. doi:10.1007/s11010-020-03865-w
Yuan, L., Li, Q., Zhang, Z., Liu, Q., Wang, X., & Fan, L. (2020). Tanshinone IIA inhibits the adipogenesis and inflammatory response in ox-LDL-challenged human monocyte-derived macrophages via regulating miR-130b/WNT5A. Journal of Cellular Biochemistry, 121(2), 1400-1408. doi:10.1002/jcb.29375
Yuan, X., Chen, J., & Dai, M. (2016). Paeonol promotes microRNA-126 expression to inhibit monocyte adhesion to ox-LDL-injured vascular endothelial cells and block the activation of the PI3K/Akt/NF-kappaB pathway. International Journal of Molecular Medicine, 38(6), 1871-1878. doi:10.3892/ijmm.2016.2778
Zang, H. L., Li, Y. H., & Huang, G. M. (2020). Long-chain non-coding RNA Linc00888 promotes the proliferation and migration of esophageal cancer cells by downregulating miR-34a expression. European Review for Medical and Pharmacological Sciences, 24(21), 11081-11089. doi:10.26355/eurrev_202011_23594
Zeng, P., Yang, J., Liu, L., Yang, X., Yao, Z., Ma, C., … Chen, Y. (2021). ERK1/2 inhibition reduces vascular calcification by activating miR-126-3p-DKK1/LRP6 pathway. Theranostics, 11(3), 1129-1146. doi:10.7150/thno.49771
Zhang, H., Xu, Z., Zhao, H., Wang, X., Pang, J., Li, Q., … Ling, W. (2020). Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose-response manner in subjects with dyslipidemia. Redox biology, 32, 101474. doi:10.1016/j.redox.2020.101474
Zhang, M., Zhu, Y., Zhu, J., Xie, Y., Wu, R., Zhong, J., … Jiang, L. (2022). circ_0086296 induced atherosclerotic lesions via the IFIT1/STAT1 feedback loop by sponging miR-576-3p. Cellular & Molecular Biology Letters, 27(1), 80. doi:10.1186/s11658-022-00372-2
Zhang, R. N., Zheng, B., Li, L. M., Zhang, J., Zhang, X. H., & Wen, J. K. (2014). Tongxinluo inhibits vascular inflammation and neointimal hyperplasia through blockade of the positive feedback loop between miR-155 and TNF-alpha. American journal of physiology. Heart and circulatory physiology, 307(4), H552-562. doi:10.1152/ajpheart.00936.2013
Zhang, X., Wang, Z., Li, W., Huang, R., Zheng, D., & Bi, G. (2020). MicroRNA-217-5p ameliorates endothelial cell apoptosis induced by ox-LDL by targeting CLIC4. Nutrition, metabolism, and cardiovascular diseases : NMCD, 30(3), 523-533. doi:10.1016/j.numecd.2019.09.027
Zhang, Y., Qin, W., Zhang, L., Wu, X., Du, N., Hu, Y., … Yang, B. (2015). MicroRNA-26a prevents endothelial cell apoptosis by directly targeting TRPC6 in the setting of atherosclerosis. Scientific Reports, 5, 9401. doi:10.1038/srep09401
Zhao, X. S., Zheng, B., Wen, Y., Sun, Y., Wen, J. K., & Zhang, X. H. (2019). Salvianolic acid B inhibits Ang II-induced VSMC proliferation in vitro and intimal hyperplasia in vivo by downregulating miR-146a expression. Phytomedicine : international journal of phytotherapy and phytopharmacology, 58, 152754. doi:10.1016/j.phymed.2018.11.014
Zhou, S., Sun, Y., Zhao, K., Gao, Y., Cui, J., Qi, L., & Huang, L. (2020). miR21/PTEN pathway mediates the cardioprotection of geniposide against oxidized lowdensity lipoproteininduced endothelial injury via suppressing oxidative stress and inflammatory response. International Journal of Molecular Medicine, 45(5), 1305-1316. doi:10.3892/ijmm.2020.4520
Zhu, L., Gong, X., Gong, J., Xuan, Y., Fu, T., Ni, S., … Ji, N. (2020). Notoginsenoside R1 upregulates miR-221-3p expression to alleviate ox-LDL-induced apoptosis, inflammation, and oxidative stress by inhibiting the TLR4/NF-kappaB pathway in HUVECs. Brazilian Journal of Medical and Biological Research, 53(6), e9346. doi:10.1590/1414-431x20209346
Zhu, Y., Xian, X., Wang, Z., Bi, Y., Chen, Q., Han, X., … Chen, R. (2018). Research progress on the relationship between atherosclerosis and inflammation. Biomolecules, 8(3)doi:10.3390/biom8030080
TABLE 1 Active monomers of traditional Chinese medicine and their ncRNA targets