Active monomers ncRNA Target Genes Related Hallmark Model References
Geniposide
miR-101
MKP-1
Inhibits inflammation
In vivo: ApoE−/− mice In vitro: RAW264.7
(S. Cheng et al., 2019)
miR-21 PTEN Inhibits inflammation and oxidative stress In vitro: HUVECs (Zhou et al., 2020)
Astragaloside IV circ-0000231 miR-135a-5p Relieves endothelial cell damage In vitro: HUVECs (Shao et al., 2021)
miR-33a
ABCA1
Promotes the outflow of cholesterol
In vivo: ApoE−/− mice In vitro: THP-1
(H. W. Qin et al., 2018)
miR-17-5p
PCSK9/VLDLR
Inhibits inflammation
In vivo: ApoE−/− mice In vitro: VSMCs
(H. W. Qin et al., 2022)
lncRNA H19
DUSP5
Inhibits autophagy and mineralization
In vivo: ApoE−/− mice C57BL/6J mice In vitro: HA-VSMCs
(Z. Song et al., 2019)
Notoginsenoside R1 miR-132 MGP Inhibits the apoptosis, migration, and release of adhesion-related molecules of cells In vitro: HUVECs (C. Fu et al., 2018)
miR-147a MyD88 Inhibits inflammation and oxidative stress In vitro: HUVECs (X. Q. Li & Huang, 2021)
miR-221-3p TLR4 Inhibits apoptosis, inflammation, and oxidative stress In vitro: HUVECs (L. Zhu et al., 2020)
miR-34a SIRT1/p53 Delays endothelial cell aging In vitro: HUVECs (Lai et al., 2018)
Tanshinone IIA miR-130b WNT5A Inhibits inflammation and adipogenesis In vitro: THP-1 (L. Yuan et al., 2020)
miR-712-5p ? Inhibits inflammation and cell proliferation In vitro: VSMCs (Y. Qin et al., 2020)
miR-375
KLF4
Enhances autophagy and M2 polarization of macrophages
In vivo: ApoE−/− mice In vitro: RAW264.7
(W. Chen et al., 2019)
miR-21-5p TPM1 Inhibits cell proliferation and migration In vitro: HASMCs (Jia et al., 2019)
Salvianolic acid B
miR-146a
?
Inhibits cell proliferation
In vivo: Carotid bifurcation ligated mice In vitro: VSMCs
(Zhao et al., 2019)
Tanshinol
lncRNA TUG1
miR-26a
Inhibits apoptosis
In vivo: ApoE−/− mice In vitro: HAECs, ECV304 cells
(C. Chen et al., 2016)
Genkwanin miR-101 MKP-1 Inhibits inflammation In vitro: RAW264.7 (Y. Gao et al., 2014)
Dihydromyricetin
miR-21
DDAH1
Reduces lipid burden
In vivo: ApoE−/− mice In vitro: HUVECs,THP-1
(D. Yang et al., 2020)
miR-21 DDAH1 Increases NO production and weakens endothelial dysfunction In vitro: HUVECs (D. Yang et al., 2018)
Sulforaphane miR-34a SIRT1 Reduces oxidative stress In vitro: HUVECs (T. Li et al., 2021)
Cyanidin-3-O-glucoside
miR-204-5p
SIRT1
Inhibits inflammation and endothelial cell apoptosis
In vivo: Rabbit model of HFD + balloon catheter injury In vitro: HUVECs
(Z. Wang et al., 2020)
Baicalin
miR-126-5p
HMGB1
Inhibits cell proliferation and migration
ex vivo:Blood of atherosclerosis patients and healthy people In vitro: VSMCs
(Z. Chen et al., 2019)
Curcumin
lncRNA MIAT
EZH2
Inhibits apoptosis and proliferation
In vivo: ApoE−/− mice In vitro: HUVECs
(Ouyang et al., 2022)
miR-125a-5p SIRT6 Promotes cholesterol efflux In vitro: THP-1 (C. Tan et al., 2021)
EGCG miR-33a ABCA1 Promotes cholesterol efflux In vitro: THP-1 (H. X. Yang et al., 2016)
Ginsenoside Rb2 miR-216a Smad3 Inhibits inflammation and aging In vitro: HUVECs, HAECs (Y. Chen et al., 2021)
Paeonol
miR-223
STAT3
Inhibits inflammation
In vivo: ApoE−/− mice In vitro: HUVECs
(Y. Liu et al., 2018)
miR-223
?
Inhibits inflammation
In vivo: SD rats In vitro: RAECs
(Shi et al., 2020)
miR-126
PI3K
Inhibits monocyte adhesion to endothelial cells
In vivo: SD rats In vitro: VECs isolated from the thoracic aorta of rats
(X. Yuan et al., 2016)
miR-21
PTEN
Inhibits inflammation
In vivo: SD rats In vitro: VECs isolated from the thoracic aorta of rats
(Y. R. Liu et al., 2014)
miR-30a
Beclin-1
Inhibits autophagy of endothelial cells
In vivo: SD rats In vitro: VECs isolated from the thoracic aorta of rats
(C. Li et al., 2018)
miR-338-3p TET2 Promotes growth of endothelial cells In vitro: VECs isolated from the thoracic aorta of rats (J. Yin et al., 2019)
Puerarin miR-29b-3p IGF1 Inhibits inflammation and proliferation In vitro: hVSMCs (J. Li et al., 2023)