3.14 Puerarin
Pueraria lobata is the dried roots of legumes Pueraria lobata(Willd.) Ohwi and Pueraria thunbergiana (Siebold & Zucc.) Benth.. It is clinically used in the treatment of cardiovascular and cerebrovascular diseases (S. Wang, Zhang, Wang, Gao, & Dai, 2020). Puerarin, an active monomer in Pueraria lobata, was reported to inhibit the proliferation and inflammation of VSMCs in atherosclerosis by reducing the expression of miR-29b-3p, thereby increasing the expression of insulin-like growth factor 1 (IGF1) (J. Li et al., 2023). Therefore, puerarin may have a beneficial effect in the treatment of atherosclerosis by regulating miRNA.