Geniposide
|
miR-101
|
MKP-1
|
Inhibits inflammation
|
In vivo: ApoE−/− mice
In vitro: RAW264.7
|
(S. Cheng et al., 2019)
|
|
miR-21 |
PTEN |
Inhibits inflammation and oxidative stress |
In
vitro: HUVECs |
(Zhou et al., 2020) |
Astragaloside IV |
circ-0000231 |
miR-135a-5p |
Relieves endothelial
cell damage |
In vitro: HUVECs |
(Shao et al.,
2021) |
|
miR-33a
|
ABCA1
|
Promotes the outflow of cholesterol
|
In vivo: ApoE−/− mice
In vitro: THP-1
|
(H. W. Qin et al., 2018)
|
|
miR-17-5p
|
PCSK9/VLDLR
|
Inhibits inflammation
|
In vivo: ApoE−/− mice
In vitro: VSMCs
|
(H. W. Qin et al., 2022)
|
|
lncRNA H19
|
DUSP5
|
Inhibits autophagy and mineralization
|
In vivo: ApoE−/− mice C57BL/6J mice
In vitro: HA-VSMCs
|
(Z. Song et al., 2019)
|
Notoginsenoside R1 |
miR-132 |
MGP |
Inhibits the apoptosis, migration, and release of adhesion-related
molecules of cells |
In vitro: HUVECs |
(C. Fu et al.,
2018) |
|
miR-147a |
MyD88 |
Inhibits inflammation and oxidative stress |
In vitro: HUVECs |
(X. Q. Li & Huang, 2021) |
|
miR-221-3p |
TLR4 |
Inhibits apoptosis, inflammation, and oxidative
stress |
In vitro: HUVECs |
(L. Zhu et al., 2020) |
|
miR-34a |
SIRT1/p53 |
Delays endothelial cell aging |
In vitro:
HUVECs |
(Lai et al., 2018) |
Tanshinone IIA |
miR-130b |
WNT5A |
Inhibits inflammation and
adipogenesis |
In vitro: THP-1 |
(L. Yuan et al.,
2020) |
|
miR-712-5p |
? |
Inhibits inflammation and cell proliferation |
In vitro: VSMCs |
(Y. Qin et al., 2020) |
|
miR-375
|
KLF4
|
Enhances autophagy and M2 polarization of macrophages
|
In vivo: ApoE−/− mice
In vitro: RAW264.7
|
(W. Chen et al., 2019)
|
|
miR-21-5p |
TPM1 |
Inhibits cell proliferation and migration |
In vitro: HASMCs |
(Jia et al., 2019) |
Salvianolic acid B
|
miR-146a
|
?
|
Inhibits cell proliferation
|
In vivo: Carotid bifurcation ligated mice
In vitro: VSMCs
|
(Zhao et al., 2019)
|
Tanshinol
|
lncRNA TUG1
|
miR-26a
|
Inhibits apoptosis
|
In vivo: ApoE−/− mice
In vitro: HAECs, ECV304 cells
|
(C. Chen et al., 2016)
|
Genkwanin |
miR-101 |
MKP-1 |
Inhibits inflammation |
In vitro:
RAW264.7 |
(Y. Gao et al., 2014) |
Dihydromyricetin
|
miR-21
|
DDAH1
|
Reduces lipid burden
|
In vivo: ApoE−/− mice
In vitro: HUVECs,THP-1
|
(D. Yang et al., 2020)
|
|
miR-21 |
DDAH1 |
Increases NO production and weakens endothelial
dysfunction |
In vitro: HUVECs |
(D. Yang et al.,
2018) |
Sulforaphane |
miR-34a |
SIRT1 |
Reduces oxidative stress |
In
vitro: HUVECs |
(T. Li et al., 2021) |
Cyanidin-3-O-glucoside
|
miR-204-5p
|
SIRT1
|
Inhibits inflammation and endothelial cell apoptosis
|
In vivo: Rabbit model of HFD + balloon catheter injury
In vitro: HUVECs
|
(Z. Wang et al., 2020)
|
Baicalin
|
miR-126-5p
|
HMGB1
|
Inhibits cell proliferation and migration
|
ex vivo:Blood of atherosclerosis patients and healthy people
In vitro: VSMCs
|
(Z. Chen et al., 2019)
|
Curcumin
|
lncRNA MIAT
|
EZH2
|
Inhibits apoptosis and proliferation
|
In vivo: ApoE−/− mice
In vitro: HUVECs
|
(Ouyang et al., 2022)
|
|
miR-125a-5p |
SIRT6 |
Promotes cholesterol efflux |
In vitro:
THP-1 |
(C. Tan et al., 2021) |
EGCG |
miR-33a |
ABCA1 |
Promotes cholesterol efflux |
In vitro:
THP-1 |
(H. X. Yang et al., 2016) |
Ginsenoside Rb2 |
miR-216a |
Smad3 |
Inhibits inflammation and aging |
In vitro: HUVECs, HAECs |
(Y. Chen et al., 2021) |
Paeonol
|
miR-223
|
STAT3
|
Inhibits inflammation
|
In vivo: ApoE−/− mice
In vitro: HUVECs
|
(Y. Liu et al., 2018)
|
|
miR-223
|
?
|
Inhibits inflammation
|
In vivo: SD rats
In vitro: RAECs
|
(Shi et al., 2020)
|
|
miR-126
|
PI3K
|
Inhibits monocyte adhesion to endothelial cells
|
In vivo: SD rats
In vitro: VECs isolated from the thoracic aorta of rats
|
(X. Yuan et al., 2016)
|
|
miR-21
|
PTEN
|
Inhibits inflammation
|
In vivo: SD rats
In vitro: VECs isolated from the thoracic aorta of rats
|
(Y. R. Liu et al., 2014)
|
|
miR-30a
|
Beclin-1
|
Inhibits autophagy of endothelial cells
|
In vivo: SD rats
In vitro: VECs isolated from the thoracic aorta of rats
|
(C. Li et al., 2018)
|
|
miR-338-3p |
TET2 |
Promotes growth of endothelial cells |
In
vitro: VECs isolated from the thoracic aorta of rats |
(J. Yin et al.,
2019) |
Puerarin |
miR-29b-3p |
IGF1 |
Inhibits inflammation and proliferation |
In vitro: hVSMCs |
(J. Li et al., 2023) |