3.9 Baicalin
Baicalin, one of the flavonoid compounds, is the main active component of traditional Chinese medicine Scutellaria baicalensis Georgi (C. Li, Zhou, Lin, & Zuo, 2009). It has been shown that baicalin can alleviate the development of atherosclerosis through its anti-adipogenic, anti-inflammatory and antioxidant effects (Wu et al., 2018). The expression of miR-126 was found to be reduced in the peripheral blood of atherosclerotic patients (Y. Jiang et al., 2014). High mobility histone B1 (HMGB1) is an essential facilitator of atherosclerosis by enhancing inflammation (Boteanu et al., 2017). It has been found that baicalin induces the upregulation of miR-126-5p and the downregulation of HMGB1, inhibiting ox-LDL-induced proliferation and migration of VSMCs (Z. Chen et al., 2019).