3.11 EGCG
EGCG
is the most abundant catechin in green tea. EGCG has been shown to has
various pharmacological effects including the anti-atherosclerotic
effect, which is primarily achieved by promoting intracellular
cholesterol efflux in macrophages (J. Jiang et al., 2012). Recent
studies showed that miR-33a is an upstream regulator of ABCA1
(Wijesekara et al., 2012) and EGCG exerts anti-atherosclerotic effect by
reducing miR-33a, thereby upregulating ABCA1 and promoting the efflux of
cholesterol in macrophages (H. X. Yang, Gao, Jiang, & Liu, 2016).