3.11 EGCG
EGCG is the most abundant catechin in green tea. EGCG has been shown to has various pharmacological effects including the anti-atherosclerotic effect, which is primarily achieved by promoting intracellular cholesterol efflux in macrophages (J. Jiang et al., 2012). Recent studies showed that miR-33a is an upstream regulator of ABCA1 (Wijesekara et al., 2012) and EGCG exerts anti-atherosclerotic effect by reducing miR-33a, thereby upregulating ABCA1 and promoting the efflux of cholesterol in macrophages (H. X. Yang, Gao, Jiang, & Liu, 2016).