Background
There is growing evidence to implicate Staphylococcus aureus(S. aureus ) in the pathogenesis of recalcitrant chronic
rhinosinusitis (CRS). Our group has demonstrated the ability of S.
aureus to internalise within mast cells in nasal polyps and this may
mediate disease recalcitrance. We investigated carriage of virulence
genes in CRS-related S. aureus strains and its influence on the
bacteria’s ability to localise and survive intracellularly.