CONCLUSION
Tamoxifen potentially interacts with NNRTIs like rilpivirine and
doravirine reducing their concentrations. This case report suggests that
anastrozole may be used instead of tamoxifen for the treatment of
gynecomastia in men living with HIV who are taking NNRTIs or PIs.
Aromatase inhibitors may be considered for use for gynecomastia
management, to avoid drug-drug interactions but further studies are
needed to confirm these findings.