3.3 Correlation of TAC exposure across different time periods
The trend-lines for TAC C0 and IPV are depicted in Figure 2, illustrating significant fluctuations in TAC concentration and consistently high IPV values across all time periods. Furthermore, the change trends of these parameters at different time points exhibit similarity. TAC C0 and IPV showed significant correlation between 3–12 months and 12–24 months (TAC C0: r = 0.541, P < 0.001; TAC IPV: r = 0.231, P = 0.002), so we used the data during 3–12 months for all further analyses (n = 224). The distribution of the TAC C0 and IPV during this time period are shown in Figure S1. In the outcome analysis, TAC C0 were categorized into two groups: High C0 (TAC C0 >= 8 ng/mL) and Low C0 (TAC C0 < 8 ng/mL), while TAC IPV values were classified as High IPV (TAC IPV >= 30%) and Low IPV (TAC IPV < 30%) (Supplementary Figure 1).
3.4 Occurrence and risk factors for clinical outcomes