3.5 Impact of combined TAC exposure on clinical outcomes
Since both TAC C0 and IPV showed significance in outcome analysis, we combined these 2 parameters together and further stratified the study population into 3 groups: High C0/Low IPV group, High C0/High IPV & Low C0/Low IPV group and Low C0/High IPV group (Figure 4). Notably, patients from High C0/Low IPV group exhibited statistically significant lower incidence of DSA (Figure 5A, Log rankP = 0.01) and superior survival rate compared with Low C0/High IPV group (Figure 5C, Log rank P = 0.001).
Table 3 shows the results of the Cox regression analysis of DSA and survival according to TAC C0/IPV status. After adjusting for age, sex, BMI, and factors with a P value < 0.2 in univariate analysis, the adjusted HR of Low C0/High IPV for DSA was 4.534 (1.326–15.507) (P = 0.016), while for survival it was 4.205 (1.739–10.168) (P = 0.001), surpassing the predictive power of TAC C0 or IPV alone.