Author (Year of publication)
Sex/Age (years)
Background/comorbidities
Vaccine type (Technology)
Number of doses
Time after COVID-19 vaccination
Clinical manifestations/Physical exam (signs)
Vital functions
Laboratory
Image tests
Pathology (Histology)
Final diagnostic
Treatment (medical or surgical)
Development -Recovery time (medical or surgical)
(2022)13
Female 69
None
Pfizer-BioNTech (mRNA)
Third
24 hours
Acute abdominal pain
BP: 96/61mm/Hg HR: 107 beats/min RR: 18 breaths/min T: 36.7 °C SpO2: 93% RBC: 3.73 × 1012/L Hb: 115 g/L Hct: 34.8% Neutrophils: 7.6 × 109/L Cre: 1.17mg/dL BUN: 21 mg/dL CT: Perforated acute appendicitis with appendicolith visualized at the base of the appendix with associated mesenteric fat stranding, multiloculated free fluid and trace free air
None
Acute appendicitis (perforated appendicitis)
Laparoscopic appendectomy converted by ileocecal resection
Recovered- Discharged at 6 days
Female 58
Left quadrantectomy with radiotherapy for breast cancer and hypertension
Pfizer-BioNTech (mRNA)
First
2 days
Acute abdominal pain in the right iliac fossa Fever Nausea Vomiting
The abdomen painful on deep palpation in RIF and hypogastrium
Hb: 125 g/L WBC: 12.1 × 109/L Neutrophils: 78.4% Fibrinogen: 636.0 mg/dL PT: 13.3 s Ultrasound: fluid collection in the right inferior fossa and thickening of the cecal wall. CT: distended appendix with thickened walls.
Diffuse acute and chronic inflammatory infiltrates with scattered non‐necrotizing granulomas throughout all layers of the appendiceal wall
Acute appendicitis
Laparoscopic appendectomy
Recovered- Discharged at 4 days
Kawano et al. (2022)22 Male 19
None
Modern (mRNA)
Second
28 days
Abdominal pain Vomiting Loss appetite BP: 79/50 mmH HR: 140 bpm T:38.6°C BMI: 16,3 kg/m 2 WBC :12.2 × 109/L CRP: 10,27 mg/L D-dimer: 1600 ug/L hsTnT : 3.67 ng/mL
CT: swollen appendix
None
Acute appendicitis Fulminant Myocarditis
Steroids and antibiotics
Recovered
Cieślewicz et al. (2021)23 Female 29
None
Pfizer-BioNTech (mRNA)
First
20 h
Abdominal pain
T: 40°C
WBC: 13 × 109/L %NEUT: 75.6 % Urine amylase: 544 U/L CRP: 128 mg/L
Abdominal USG: pancreas clearly visible in the head and body area not enlarged, homogeneous
None
Pancreatitis acute
Fluid resuscitation, pain control, and nutritional support
Recovered- Discharged
Parkash et al. (2021)24
Female 96
Heart failure, hypertension, hypothyroidism
Pfizer-BioNTech (mRNA)
First
2 days
Epigastric pain radiating to the right lower chest Nausea
No data
Amylase: 4036 U/L
CT: No findings
None
Acute pancreatitis
Hydration, analgesics
Recovered
(2022)14
Male 82 Coronary artery disease, prostate cancer, proctocolitis complicated by radiation Hypothyroidism and gastroesophageal reflux disease
Pfizer-BioNTech (mRNA)
Third
Few hours
Epigastric abdominal pain acute with radiation to back Nausea and two episodes of vomiting
Not found
Lipase: 2257 U/L Triglyceride: 57 mg/dL Calcium: 9.3 mg/dL CT: moderate peripancreatic fat stranding with tracking fluid into the mesenteric root, suggestive for acute interstitial pancreatitis, without evidence of necrosis
None
Acute pancreatitis
IV fluids, acetaminophen, hydromorphone, and metoclopramide
Recovered
(2022)25
Female 24
Pregnant (31 weeks of gestation)
Pfizer-BioNTech (mRNA)
First
1 week
Severe epigastric pain radiating to the back Nausea Vomiting BP: 140/90 mmHg HR: 106 beats/min RR:22 breaths/min T: 39 °C SpO2: 98% WBC: 17 x 109/L Lipase 4376 U/L Amylase: 83 U/L CT: bulky pancreas with mild enhancement and marked peripancreatic fat stranding with inflammation, suggestive of acute interstitial edematous pancreatitis
None
Acute pancreatitis
Intravenous hydration, antibiotics and proton pump inhibition and pain relief.
Recovered-Spontaneous labor during hospitalization
(2022)26
Female 71
Hypertension, hyperlipidemia, cerebral infarction
Pfizer-BioNTech (mRNA)
First
2 days
Acute upper abdominal pain Vomiting BP: 142/86 mmHg HR: 92 beats/min T: 37.3 °C Lipase: 383 U/L Amylase: 1043 U/L CT: diffuse enlargement of the pancreas with ill-defined parenchymal contours
None
Acute pancreatitis
IV hydration, antibiotics, proton pump inhibition
Recovered
Alrashdi et al. (2022)27 Female 22
None
Pfizer-BioNTech (mRNA)
First
1 week
Abdominal pain Nausea Vomiting Erythematous maculopapular rashes CAO BP: 118/75 mmHg HR: 80 beats/min T: 37 °C WBC: 13 × 109/L Amylase: 181 U/L Lipase: 185 U/L AST: 301 UI/L ALT: 81 UI/L
CT: Edematous pancreas with loss of normal lobulation
None
Autoimmune pancreatitis acute due to SLE
MP, HCQ, AZA
Recovered- Discharged at 1 week
(2023)28
Female 28
None
BBIBP-CorV (Sinopharm)
Second
3 months
Acute abdominal pain Nausea Hemoptysis Aphagia Constipation BP: 130/70 mmHg HR: 101 beats/min RR: 13 breaths/min T:37 °C BMI: 25.7 kg/m2 WBC: 8.4 × 109/L Lipase: 156 U/L Amyla se: 1079 U/L ALT: 80U/L AST: 44 U/L TG: 1562 mg/dL Glycemia: 203 mg/dL CT: Homogeneous enlargement of the pancreas, extensive peri-pancreatic fat and peri-pancreatic fluid was observed
None
Acute pancreatitis
Fluid therapy, antibiotics.
Recovered
Bangolo et al. (2023)29 Male 34
None
Johnson & Johnson / Jassen vaccine (Viral vector)
First
1 day
Epigastric pain Nausea Subjective fever Shivering Tachycardic Diaphoretic T: 38.28 °C WBC: 18.9 × 109/L Lipase:1026 U/L T-bil: 9.9 mg/dL ALP: 48 U/L CRP: 15 mm/h BUN: 45 mg/dL Cre: 2.19 mg/dL
CT: consistent with acute necrotizing pancreatitis
None
Acute Pancreatitis
Fluid resuscitation (lactated ringer), pain control, and nutritional support
Recovered
Stöllberger et al. (2023)30 Female 31
Allergic asthma, psoriatic arthritis, neurogenic bladder, and cholecystolithiasis
Pfizer-BioNTech (mRNA)
Second
2 days
Abdominal pain Nausea
None
WBC: 12.6 × 109/L AAE: 418 U/L Lipase: 1162 U/L CT on the day of admission: necrotizing pancreatitis with enlarged edematous pancreas. CT image after 10 days: shows a large acute necrotic collection in the lesser sac
None
Pancreatitis
EAT with CTX, transgastric drainage
Recovered- Discharged at 19 days
Ajmera et al. (2022)15 Male 41
Bipolar depression, asthma, and obesity
Modern (mRNA)
Third
1 day
Abdominal pain Diarrhea Sweating Loss appetite BP: 148/100 mm/Hg HR: 95 beats/min RR: 18 breaths/min T: 36.5 °C SpO2: 100% BMI: 40 kg/m2 WBC: 13.5 × 109/L Hb: 147 g/L
CT: showed acute diverticulitis of the mid-transverse colon, with adjacent contained micro-perforation
None
Diverticulitis acute
NBM, EAT, intravenous hydration with normal saline
Recovered
Kyungu et al. (2022)31
Male 29
None
Johnson & Johnson/ Janssen (Viral vector)
First
2 days
Acute abdominal pain Nausea Fever Dark colored urine BP: 153/121 mmHg HR: 93 beats/min RR: 20 breaths/min T: 39.2°C SpO2: 95% WBC: 2.83 x 109/L Platelet: 79 x 109/L AST: 493.9 U/L ALT: 244.7U/L GGT: 85U/L CRP: 148.62 mg/L Ultrasound: Normal appearing liver (141 mm) without evidence of intrahepatic biliary dilatation. Wall thickened 7.7 mm without gallstones
None
Acute acalculous cholecystitis
Analgesics, hydration (ringer lactate), antibiotics (cefuroxime 500mg)
Recovered- 2 weeks
Wahlen et al. (2022)16 Female 52
None
Pfizer-BioNTech (mRNA)
Third
8 h
Abdominal pain Shivering Nausea Vomiting Anuria HR: 100 beats/min T: 38°C WBC :15.8 × 109/L ANC: 14.6 × 109/L ALT: 89 U/L CRP: 10.8 mg/L
Ultrasound: Common bile duct was of normal caliber with no intrahepatic biliary dilatation.
None
Acalculous cholecystitis
Fluid resuscitation, paracetamol, and nutritional support
Recovered
Vadioaloo et al. (2022)32 Male 72
Hypertension, atrial fibrillation with stroke
Pfizer-BioNTech (mRNA)
First
6 hours
Colicky abdominal pain Diarrhea
No data
Eosinophil count:6.84 x 109/L
EGD: showed antral erythematous gastritis
Mucosal lymphoplasmacytic cell infiltration with increased eosinophil
Eosinophilic Colitis
Any, resolved spontaneously
Recovered
Cui et al. (2022)17 Female 48
None
BBIBP-CorV (Sinopharm)
Second
1 day
Abdominal pain Hematochezia Fatigue BP: 140/85 mmHg HR: 80 beats/min RR: 19 breaths/min T: 36.2 °C BMI: 21,1 kg/m 2 D-dimer: 329 ug/L FDP: 2.5 mg/L Lactic acid: 2.60 mmol/L
CT: edema and bowel wall thickening with hypodensity in the sigmoid colon and descending colon
None
Ischemic colitis
Pinaverium bromide and aspirin enteric-coated tablets
Recovered